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Protective Effect of Solanum nigrum Leaves Extract on Immobilization Stress Induced Changes in Rat's Brain

The prophylactic or curative antioxidant efficacy of crude extract and the active constituent of S. nigrum leaves were evaluated in modulating inherent antioxidant system altered due to immobilization stress in rat brain tissues, in terms of measurement of glutathione (GSH), lipid peroxidation (thio...

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Autores principales: Zaidi, Syed Kashif, Hoda, Md. Nasrul, Tabrez, Shams, Ansari, Shakeel Ahmed, Jafri, Mohammad Alam, Shahnawaz Khan, Mohd, Hasan, Shirin, Alqahtani, Mohammed H., Mohammed Abuzenadah, Adel, Banu, Naheed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934381/
https://www.ncbi.nlm.nih.gov/pubmed/24665335
http://dx.doi.org/10.1155/2014/912450
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author Zaidi, Syed Kashif
Hoda, Md. Nasrul
Tabrez, Shams
Ansari, Shakeel Ahmed
Jafri, Mohammad Alam
Shahnawaz Khan, Mohd
Hasan, Shirin
Alqahtani, Mohammed H.
Mohammed Abuzenadah, Adel
Banu, Naheed
author_facet Zaidi, Syed Kashif
Hoda, Md. Nasrul
Tabrez, Shams
Ansari, Shakeel Ahmed
Jafri, Mohammad Alam
Shahnawaz Khan, Mohd
Hasan, Shirin
Alqahtani, Mohammed H.
Mohammed Abuzenadah, Adel
Banu, Naheed
author_sort Zaidi, Syed Kashif
collection PubMed
description The prophylactic or curative antioxidant efficacy of crude extract and the active constituent of S. nigrum leaves were evaluated in modulating inherent antioxidant system altered due to immobilization stress in rat brain tissues, in terms of measurement of glutathione (GSH), lipid peroxidation (thiobarbituric acid reactive substances, TBARS), and free radical scavenging enzymes activities. Rats were treated with single dose of crude extract of S. nigrum prior to and after 6 h of immobilization stress exposure. Exposure to immobilization stress resulted in a decrease in the brain levels of glutathione, SOD, GST, and catalase, with an increase in thiobarbituric acid reactive substances (TBARS) levels. Treatment of S. nigrum extract and its active constituents to both pre- and poststressed rats resulted in significant modulation in the above mentioned parameters towards their control values with a relative dominance by the latter. Brain is vulnerable to stress induced prooxidant insult due to high levels of fat content. Thus, as a safe herbal medication the S. nigrum leaves extract or its isolated constituents can be used as nutritional supplement for scavenging free radicals generated in the brain due to physical or psychological stress or any neuronal diseases per se.
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spelling pubmed-39343812014-03-24 Protective Effect of Solanum nigrum Leaves Extract on Immobilization Stress Induced Changes in Rat's Brain Zaidi, Syed Kashif Hoda, Md. Nasrul Tabrez, Shams Ansari, Shakeel Ahmed Jafri, Mohammad Alam Shahnawaz Khan, Mohd Hasan, Shirin Alqahtani, Mohammed H. Mohammed Abuzenadah, Adel Banu, Naheed Evid Based Complement Alternat Med Research Article The prophylactic or curative antioxidant efficacy of crude extract and the active constituent of S. nigrum leaves were evaluated in modulating inherent antioxidant system altered due to immobilization stress in rat brain tissues, in terms of measurement of glutathione (GSH), lipid peroxidation (thiobarbituric acid reactive substances, TBARS), and free radical scavenging enzymes activities. Rats were treated with single dose of crude extract of S. nigrum prior to and after 6 h of immobilization stress exposure. Exposure to immobilization stress resulted in a decrease in the brain levels of glutathione, SOD, GST, and catalase, with an increase in thiobarbituric acid reactive substances (TBARS) levels. Treatment of S. nigrum extract and its active constituents to both pre- and poststressed rats resulted in significant modulation in the above mentioned parameters towards their control values with a relative dominance by the latter. Brain is vulnerable to stress induced prooxidant insult due to high levels of fat content. Thus, as a safe herbal medication the S. nigrum leaves extract or its isolated constituents can be used as nutritional supplement for scavenging free radicals generated in the brain due to physical or psychological stress or any neuronal diseases per se. Hindawi Publishing Corporation 2014 2014-02-09 /pmc/articles/PMC3934381/ /pubmed/24665335 http://dx.doi.org/10.1155/2014/912450 Text en Copyright © 2014 Syed Kashif Zaidi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zaidi, Syed Kashif
Hoda, Md. Nasrul
Tabrez, Shams
Ansari, Shakeel Ahmed
Jafri, Mohammad Alam
Shahnawaz Khan, Mohd
Hasan, Shirin
Alqahtani, Mohammed H.
Mohammed Abuzenadah, Adel
Banu, Naheed
Protective Effect of Solanum nigrum Leaves Extract on Immobilization Stress Induced Changes in Rat's Brain
title Protective Effect of Solanum nigrum Leaves Extract on Immobilization Stress Induced Changes in Rat's Brain
title_full Protective Effect of Solanum nigrum Leaves Extract on Immobilization Stress Induced Changes in Rat's Brain
title_fullStr Protective Effect of Solanum nigrum Leaves Extract on Immobilization Stress Induced Changes in Rat's Brain
title_full_unstemmed Protective Effect of Solanum nigrum Leaves Extract on Immobilization Stress Induced Changes in Rat's Brain
title_short Protective Effect of Solanum nigrum Leaves Extract on Immobilization Stress Induced Changes in Rat's Brain
title_sort protective effect of solanum nigrum leaves extract on immobilization stress induced changes in rat's brain
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934381/
https://www.ncbi.nlm.nih.gov/pubmed/24665335
http://dx.doi.org/10.1155/2014/912450
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