Determination of Atropine in Injection with β-Cyclodextrin Modified Ion Sensitive Field Effect Transistor Sensor

A new atropine drug-FET sensor, which was made of an ISFET (ion sensitive field effect transistor) and a drug sensitive membrane prepared by adding electric active matter to a β-cyclodextrin solution, was developed. The pH influence, selectivity, response curve, reproducibility, stability, response time and life of this sensor were investigated. A preliminary application of the sensor was discussed as well. The experimental results indicated that the sensor showed a Nernst response to atropine with a slope of 58.0 mV/decade over the concentration range of 5.0×10(-3) − 1.0×10(-6) mol/L and the pH range of 5.0−8.5. The sensor detection limit was 8.0×10(-7) mol/L. The performance of this sensor was very stable when it was used to determine atropine concentration in a medicinal injection. The obtained results agreed well with the pharmacopoeia method.