Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats

A simple and sensitive HPLC method was developed for simultaneous determination of danshensu (DSS), rosmarinic acid (RA), lithospermic acid (LA), salvianolic acid B (SAB), and hyperoside (HP) in rat plasma. This method validated was successfully applied to the pharmacokinetic study of the main activ...

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Autores principales: Liu, Yu-Qiang, Cai, Qian, Liu, Chang, Bao, Feng-Wei, Zhang, Zhen-Qiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934716/
https://www.ncbi.nlm.nih.gov/pubmed/24660090
http://dx.doi.org/10.1155/2014/617367
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author Liu, Yu-Qiang
Cai, Qian
Liu, Chang
Bao, Feng-Wei
Zhang, Zhen-Qiu
author_facet Liu, Yu-Qiang
Cai, Qian
Liu, Chang
Bao, Feng-Wei
Zhang, Zhen-Qiu
author_sort Liu, Yu-Qiang
collection PubMed
description A simple and sensitive HPLC method was developed for simultaneous determination of danshensu (DSS), rosmarinic acid (RA), lithospermic acid (LA), salvianolic acid B (SAB), and hyperoside (HP) in rat plasma. This method validated was successfully applied to the pharmacokinetic study of the main active ingredients after oral administration of Radix Salviae Miltiorrhizae extract (SME), hawthorn extract (HTE), and a combination of both extracts (2.5 : 1) to rats. The results indicated that there have been great differences in pharmacokinetics between a single extract and a combination of both extracts. A combination of both extracts can enhance their bioavailabilities and delay the elimination of SAB and DSS in rats.
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spelling pubmed-39347162014-03-23 Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats Liu, Yu-Qiang Cai, Qian Liu, Chang Bao, Feng-Wei Zhang, Zhen-Qiu J Anal Methods Chem Research Article A simple and sensitive HPLC method was developed for simultaneous determination of danshensu (DSS), rosmarinic acid (RA), lithospermic acid (LA), salvianolic acid B (SAB), and hyperoside (HP) in rat plasma. This method validated was successfully applied to the pharmacokinetic study of the main active ingredients after oral administration of Radix Salviae Miltiorrhizae extract (SME), hawthorn extract (HTE), and a combination of both extracts (2.5 : 1) to rats. The results indicated that there have been great differences in pharmacokinetics between a single extract and a combination of both extracts. A combination of both extracts can enhance their bioavailabilities and delay the elimination of SAB and DSS in rats. Hindawi Publishing Corporation 2014 2014-02-10 /pmc/articles/PMC3934716/ /pubmed/24660090 http://dx.doi.org/10.1155/2014/617367 Text en Copyright © 2014 Yu-Qiang Liu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Liu, Yu-Qiang
Cai, Qian
Liu, Chang
Bao, Feng-Wei
Zhang, Zhen-Qiu
Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats
title Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats
title_full Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats
title_fullStr Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats
title_full_unstemmed Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats
title_short Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats
title_sort simultaneous determination and pharmacokinetic comparisons of multi-ingredients after oral administration of radix salviae miltiorrhizae extract, hawthorn extract, and a combination of both extracts to rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934716/
https://www.ncbi.nlm.nih.gov/pubmed/24660090
http://dx.doi.org/10.1155/2014/617367
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