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A Metabolomic Perspective on Coeliac Disease

Metabolomics is an “omic” science that is now emerging with the purpose of elaborating a comprehensive analysis of the metabolome, which is the complete set of metabolites (i.e., small molecules intermediates) in an organism, tissue, cell, or biofluid. In the past decade, metabolomics has already pr...

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Detalles Bibliográficos
Autores principales: Calabrò, Antonio, Gralka, Ewa, Luchinat, Claudio, Saccenti, Edoardo, Tenori, Leonardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934717/
https://www.ncbi.nlm.nih.gov/pubmed/24665364
http://dx.doi.org/10.1155/2014/756138
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author Calabrò, Antonio
Gralka, Ewa
Luchinat, Claudio
Saccenti, Edoardo
Tenori, Leonardo
author_facet Calabrò, Antonio
Gralka, Ewa
Luchinat, Claudio
Saccenti, Edoardo
Tenori, Leonardo
author_sort Calabrò, Antonio
collection PubMed
description Metabolomics is an “omic” science that is now emerging with the purpose of elaborating a comprehensive analysis of the metabolome, which is the complete set of metabolites (i.e., small molecules intermediates) in an organism, tissue, cell, or biofluid. In the past decade, metabolomics has already proved to be useful for the characterization of several pathological conditions and offers promises as a clinical tool. A metabolomics investigation of coeliac disease (CD) revealed that a metabolic fingerprint for CD can be defined, which accounts for three different but complementary components: malabsorption, energy metabolism, and alterations in gut microflora and/or intestinal permeability. In this review, we will discuss the major advancements in metabolomics of CD, in particular with respect to the role of gut microbiome and energy metabolism.
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spelling pubmed-39347172014-03-24 A Metabolomic Perspective on Coeliac Disease Calabrò, Antonio Gralka, Ewa Luchinat, Claudio Saccenti, Edoardo Tenori, Leonardo Autoimmune Dis Review Article Metabolomics is an “omic” science that is now emerging with the purpose of elaborating a comprehensive analysis of the metabolome, which is the complete set of metabolites (i.e., small molecules intermediates) in an organism, tissue, cell, or biofluid. In the past decade, metabolomics has already proved to be useful for the characterization of several pathological conditions and offers promises as a clinical tool. A metabolomics investigation of coeliac disease (CD) revealed that a metabolic fingerprint for CD can be defined, which accounts for three different but complementary components: malabsorption, energy metabolism, and alterations in gut microflora and/or intestinal permeability. In this review, we will discuss the major advancements in metabolomics of CD, in particular with respect to the role of gut microbiome and energy metabolism. Hindawi Publishing Corporation 2014 2014-02-09 /pmc/articles/PMC3934717/ /pubmed/24665364 http://dx.doi.org/10.1155/2014/756138 Text en Copyright © 2014 Antonio Calabrò et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Calabrò, Antonio
Gralka, Ewa
Luchinat, Claudio
Saccenti, Edoardo
Tenori, Leonardo
A Metabolomic Perspective on Coeliac Disease
title A Metabolomic Perspective on Coeliac Disease
title_full A Metabolomic Perspective on Coeliac Disease
title_fullStr A Metabolomic Perspective on Coeliac Disease
title_full_unstemmed A Metabolomic Perspective on Coeliac Disease
title_short A Metabolomic Perspective on Coeliac Disease
title_sort metabolomic perspective on coeliac disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934717/
https://www.ncbi.nlm.nih.gov/pubmed/24665364
http://dx.doi.org/10.1155/2014/756138
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