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A Metabolomic Perspective on Coeliac Disease
Metabolomics is an “omic” science that is now emerging with the purpose of elaborating a comprehensive analysis of the metabolome, which is the complete set of metabolites (i.e., small molecules intermediates) in an organism, tissue, cell, or biofluid. In the past decade, metabolomics has already pr...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934717/ https://www.ncbi.nlm.nih.gov/pubmed/24665364 http://dx.doi.org/10.1155/2014/756138 |
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author | Calabrò, Antonio Gralka, Ewa Luchinat, Claudio Saccenti, Edoardo Tenori, Leonardo |
author_facet | Calabrò, Antonio Gralka, Ewa Luchinat, Claudio Saccenti, Edoardo Tenori, Leonardo |
author_sort | Calabrò, Antonio |
collection | PubMed |
description | Metabolomics is an “omic” science that is now emerging with the purpose of elaborating a comprehensive analysis of the metabolome, which is the complete set of metabolites (i.e., small molecules intermediates) in an organism, tissue, cell, or biofluid. In the past decade, metabolomics has already proved to be useful for the characterization of several pathological conditions and offers promises as a clinical tool. A metabolomics investigation of coeliac disease (CD) revealed that a metabolic fingerprint for CD can be defined, which accounts for three different but complementary components: malabsorption, energy metabolism, and alterations in gut microflora and/or intestinal permeability. In this review, we will discuss the major advancements in metabolomics of CD, in particular with respect to the role of gut microbiome and energy metabolism. |
format | Online Article Text |
id | pubmed-3934717 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-39347172014-03-24 A Metabolomic Perspective on Coeliac Disease Calabrò, Antonio Gralka, Ewa Luchinat, Claudio Saccenti, Edoardo Tenori, Leonardo Autoimmune Dis Review Article Metabolomics is an “omic” science that is now emerging with the purpose of elaborating a comprehensive analysis of the metabolome, which is the complete set of metabolites (i.e., small molecules intermediates) in an organism, tissue, cell, or biofluid. In the past decade, metabolomics has already proved to be useful for the characterization of several pathological conditions and offers promises as a clinical tool. A metabolomics investigation of coeliac disease (CD) revealed that a metabolic fingerprint for CD can be defined, which accounts for three different but complementary components: malabsorption, energy metabolism, and alterations in gut microflora and/or intestinal permeability. In this review, we will discuss the major advancements in metabolomics of CD, in particular with respect to the role of gut microbiome and energy metabolism. Hindawi Publishing Corporation 2014 2014-02-09 /pmc/articles/PMC3934717/ /pubmed/24665364 http://dx.doi.org/10.1155/2014/756138 Text en Copyright © 2014 Antonio Calabrò et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Calabrò, Antonio Gralka, Ewa Luchinat, Claudio Saccenti, Edoardo Tenori, Leonardo A Metabolomic Perspective on Coeliac Disease |
title | A Metabolomic Perspective on Coeliac Disease |
title_full | A Metabolomic Perspective on Coeliac Disease |
title_fullStr | A Metabolomic Perspective on Coeliac Disease |
title_full_unstemmed | A Metabolomic Perspective on Coeliac Disease |
title_short | A Metabolomic Perspective on Coeliac Disease |
title_sort | metabolomic perspective on coeliac disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934717/ https://www.ncbi.nlm.nih.gov/pubmed/24665364 http://dx.doi.org/10.1155/2014/756138 |
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