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Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis

Long-term cytokine-mediated inflammation is a risk factor for obesity and type 2 diabetes mellitus (T2DM). Our previous studies reveal significant associations between promoter single nucleotide polymorphisms (SNPs) of interleukin (IL)-4 and T2DM, as well as between SNPs in genes encoding IL-4/IL-4...

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Autores principales: Tsao, Chang-Hui, Shiau, Ming-Yuh, Chuang, Pei-Hua, Chang, Yih-Hsin, Hwang, Jaulang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934724/
https://www.ncbi.nlm.nih.gov/pubmed/24347527
http://dx.doi.org/10.1194/jlr.M041392
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author Tsao, Chang-Hui
Shiau, Ming-Yuh
Chuang, Pei-Hua
Chang, Yih-Hsin
Hwang, Jaulang
author_facet Tsao, Chang-Hui
Shiau, Ming-Yuh
Chuang, Pei-Hua
Chang, Yih-Hsin
Hwang, Jaulang
author_sort Tsao, Chang-Hui
collection PubMed
description Long-term cytokine-mediated inflammation is a risk factor for obesity and type 2 diabetes mellitus (T2DM). Our previous studies reveal significant associations between promoter single nucleotide polymorphisms (SNPs) of interleukin (IL)-4 and T2DM, as well as between SNPs in genes encoding IL-4/IL-4 receptor and high density lipoproteins. Our animal study reveals that IL-4 regulates glucose/lipid metabolism by promoting glucose tolerance and inhibiting lipid deposits. The above results strongly suggest the involvement of IL-4 in energy homeostasis. In the present study, we focus on examining the regulatory mechanism of IL-4 to lipid metabolism. Our results show that IL-4 inhibits adipogenesis by downregulating the expression of peroxisome proliferator-activated receptor-γ and CCAAT/enhancer-binding protein-α. Additionally, IL-4 promotes lipolysis by enhancing the activity and translocation of hormone sensitive lipase (HSL) in mature adipocytes, which suggests that IL-4 plays a pro-lipolytic role in lipid metabolism by boosting HSL activity. Our results demonstrate that IL-4 harbors pro-lipolysis capacity by inhibiting adipocyte differentiation and lipid accumulation as well as by promoting lipolysis in mature adipocytes to decrease lipid deposits. The above findings uncover the novel roles of IL-4 in lipid metabolism and provide new insights into the interactions among cytokine/immune responses, insulin sensitivity, and metabolism.
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spelling pubmed-39347242014-03-04 Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis Tsao, Chang-Hui Shiau, Ming-Yuh Chuang, Pei-Hua Chang, Yih-Hsin Hwang, Jaulang J Lipid Res Research Articles Long-term cytokine-mediated inflammation is a risk factor for obesity and type 2 diabetes mellitus (T2DM). Our previous studies reveal significant associations between promoter single nucleotide polymorphisms (SNPs) of interleukin (IL)-4 and T2DM, as well as between SNPs in genes encoding IL-4/IL-4 receptor and high density lipoproteins. Our animal study reveals that IL-4 regulates glucose/lipid metabolism by promoting glucose tolerance and inhibiting lipid deposits. The above results strongly suggest the involvement of IL-4 in energy homeostasis. In the present study, we focus on examining the regulatory mechanism of IL-4 to lipid metabolism. Our results show that IL-4 inhibits adipogenesis by downregulating the expression of peroxisome proliferator-activated receptor-γ and CCAAT/enhancer-binding protein-α. Additionally, IL-4 promotes lipolysis by enhancing the activity and translocation of hormone sensitive lipase (HSL) in mature adipocytes, which suggests that IL-4 plays a pro-lipolytic role in lipid metabolism by boosting HSL activity. Our results demonstrate that IL-4 harbors pro-lipolysis capacity by inhibiting adipocyte differentiation and lipid accumulation as well as by promoting lipolysis in mature adipocytes to decrease lipid deposits. The above findings uncover the novel roles of IL-4 in lipid metabolism and provide new insights into the interactions among cytokine/immune responses, insulin sensitivity, and metabolism. The American Society for Biochemistry and Molecular Biology 2014-03 /pmc/articles/PMC3934724/ /pubmed/24347527 http://dx.doi.org/10.1194/jlr.M041392 Text en Copyright © 2014 by the American Society for Biochemistry and Molecular Biology, Inc. http://creativecommons.org/licenses/by/3.0/ Author's Choice—Final version full access. Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/) applies to Author Choice Articles
spellingShingle Research Articles
Tsao, Chang-Hui
Shiau, Ming-Yuh
Chuang, Pei-Hua
Chang, Yih-Hsin
Hwang, Jaulang
Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis
title Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis
title_full Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis
title_fullStr Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis
title_full_unstemmed Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis
title_short Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis
title_sort interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934724/
https://www.ncbi.nlm.nih.gov/pubmed/24347527
http://dx.doi.org/10.1194/jlr.M041392
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