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Computational Study on the Inhibitor Binding Mode and Allosteric Regulation Mechanism in Hepatitis C Virus NS3/4A Protein

HCV NS3/4A protein is an attractive therapeutic target responsible for harboring serine protease and RNA helicase activities during the viral replication. Small molecules binding at the interface between the protease and helicase domains can stabilize the closed conformation of the protein and thus...

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Detalles Bibliográficos
Autores principales:	Xue, Weiwei, Yang, Ying, Wang, Xiaoting, Liu, Huanxiang, Yao, Xiaojun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934852/ https://www.ncbi.nlm.nih.gov/pubmed/24586263 http://dx.doi.org/10.1371/journal.pone.0087077

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