IL-17A Signaling in Colonic Epithelial Cells Inhibits Pro-Inflammatory Cytokine Production by Enhancing the Activity of ERK and PI3K

Our previous data suggested that IL-17A contributes to the inhibition of Th1 cell function in the gut. However, the underlying mechanisms remain unclear. Here we demonstrate that IL-17A signaling in colonic epithelial cells (CECs) increases TNF-α-induced PI3K-AKT and ERK phosphorylation and inhibits...

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Detalles Bibliográficos
Autores principales: Guo, Xiaoqin, Jiang, Xingwei, Xiao, Yan, Zhou, Tingting, Guo, Yueling, Wang, Renxi, Zhao, Zhi, Xiao, He, Hou, Chunmei, Ma, Lingyun, Lin, Yanhua, Lang, Xiaoling, Feng, Jiannan, Chen, Guojiang, Shen, Beifen, Han, Gencheng, Li, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934915/
https://www.ncbi.nlm.nih.gov/pubmed/24586980
http://dx.doi.org/10.1371/journal.pone.0089714

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