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Sutherlandia frutescens Ethanol Extracts Inhibit Oxidative Stress and Inflammatory Responses in Neurons and Microglial Cells
Sutherlandia frutescens (L.) R.Br. (SF) is a medicinal plant indigenous to southern Africa and used in folk and contemporary remedies for stress, chronic diseases, cancer, and HIV/AIDS. While previous studies have focused on physiological effects of SF on cellular and systemic abnormalities associat...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934922/ https://www.ncbi.nlm.nih.gov/pubmed/24587007 http://dx.doi.org/10.1371/journal.pone.0089748 |
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author | Jiang, Jinghua Chuang, Dennis Y. Zong, Yijia Patel, Jayleenkumar Brownstein, Korey Lei, Wei Lu, Chi-Hua Simonyi, Agnes Gu, Zezong Cui, Jiankun Rottinghaus, George E. Fritsche, Kevin L. Lubahn, Dennis B. Folk, William R. Sun, Grace Y. |
author_facet | Jiang, Jinghua Chuang, Dennis Y. Zong, Yijia Patel, Jayleenkumar Brownstein, Korey Lei, Wei Lu, Chi-Hua Simonyi, Agnes Gu, Zezong Cui, Jiankun Rottinghaus, George E. Fritsche, Kevin L. Lubahn, Dennis B. Folk, William R. Sun, Grace Y. |
author_sort | Jiang, Jinghua |
collection | PubMed |
description | Sutherlandia frutescens (L.) R.Br. (SF) is a medicinal plant indigenous to southern Africa and used in folk and contemporary remedies for stress, chronic diseases, cancer, and HIV/AIDS. While previous studies have focused on physiological effects of SF on cellular and systemic abnormalities associated with these diseases, little is known about its effects in the brain and immune cells in the central nervous system. Results of this study indicate that ethanol extracts of SF (SF-E) suppress NMDA-induced reactive oxygen species (ROS) production in neurons, and LPS- and IFNγ-induced ROS and nitric oxide (NO) production in microglial cells. SF-E’s action on microglial cells appears to be mediated through inhibition of the IFNγ-induced p-ERK1/2 signaling pathway which is central to regulating a number of intracellular metabolic processes including enhancing STAT1α phosphorylation and filopodia formation. The involvement of SF in these pathways suggests the potential for novel therapeutics for stress and prevention, and/or treatment of HIV/AIDS as well as other inflammatory diseases in the brain. |
format | Online Article Text |
id | pubmed-3934922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39349222014-03-04 Sutherlandia frutescens Ethanol Extracts Inhibit Oxidative Stress and Inflammatory Responses in Neurons and Microglial Cells Jiang, Jinghua Chuang, Dennis Y. Zong, Yijia Patel, Jayleenkumar Brownstein, Korey Lei, Wei Lu, Chi-Hua Simonyi, Agnes Gu, Zezong Cui, Jiankun Rottinghaus, George E. Fritsche, Kevin L. Lubahn, Dennis B. Folk, William R. Sun, Grace Y. PLoS One Research Article Sutherlandia frutescens (L.) R.Br. (SF) is a medicinal plant indigenous to southern Africa and used in folk and contemporary remedies for stress, chronic diseases, cancer, and HIV/AIDS. While previous studies have focused on physiological effects of SF on cellular and systemic abnormalities associated with these diseases, little is known about its effects in the brain and immune cells in the central nervous system. Results of this study indicate that ethanol extracts of SF (SF-E) suppress NMDA-induced reactive oxygen species (ROS) production in neurons, and LPS- and IFNγ-induced ROS and nitric oxide (NO) production in microglial cells. SF-E’s action on microglial cells appears to be mediated through inhibition of the IFNγ-induced p-ERK1/2 signaling pathway which is central to regulating a number of intracellular metabolic processes including enhancing STAT1α phosphorylation and filopodia formation. The involvement of SF in these pathways suggests the potential for novel therapeutics for stress and prevention, and/or treatment of HIV/AIDS as well as other inflammatory diseases in the brain. Public Library of Science 2014-02-25 /pmc/articles/PMC3934922/ /pubmed/24587007 http://dx.doi.org/10.1371/journal.pone.0089748 Text en © 2014 Jiang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Jiang, Jinghua Chuang, Dennis Y. Zong, Yijia Patel, Jayleenkumar Brownstein, Korey Lei, Wei Lu, Chi-Hua Simonyi, Agnes Gu, Zezong Cui, Jiankun Rottinghaus, George E. Fritsche, Kevin L. Lubahn, Dennis B. Folk, William R. Sun, Grace Y. Sutherlandia frutescens Ethanol Extracts Inhibit Oxidative Stress and Inflammatory Responses in Neurons and Microglial Cells |
title |
Sutherlandia frutescens Ethanol Extracts Inhibit Oxidative Stress and Inflammatory Responses in Neurons and Microglial Cells |
title_full |
Sutherlandia frutescens Ethanol Extracts Inhibit Oxidative Stress and Inflammatory Responses in Neurons and Microglial Cells |
title_fullStr |
Sutherlandia frutescens Ethanol Extracts Inhibit Oxidative Stress and Inflammatory Responses in Neurons and Microglial Cells |
title_full_unstemmed |
Sutherlandia frutescens Ethanol Extracts Inhibit Oxidative Stress and Inflammatory Responses in Neurons and Microglial Cells |
title_short |
Sutherlandia frutescens Ethanol Extracts Inhibit Oxidative Stress and Inflammatory Responses in Neurons and Microglial Cells |
title_sort | sutherlandia frutescens ethanol extracts inhibit oxidative stress and inflammatory responses in neurons and microglial cells |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934922/ https://www.ncbi.nlm.nih.gov/pubmed/24587007 http://dx.doi.org/10.1371/journal.pone.0089748 |
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