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Nitric Oxide Dysregulation in Platelets from Patients with Advanced Huntington Disease

Nitric oxide (NO) is a biologically active inorganic molecule involved in the regulation of many physiological processes, such as control of blood flow, platelet adhesion, endocrine function, neurotransmission and neuromodulation. In the present study, for the first time, we investigated the modulat...

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Autores principales: Carrizzo, Albino, Di Pardo, Alba, Maglione, Vittorio, Damato, Antonio, Amico, Enrico, Formisano, Luigi, Vecchione, Carmine, Squitieri, Ferdinando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934931/
https://www.ncbi.nlm.nih.gov/pubmed/24587005
http://dx.doi.org/10.1371/journal.pone.0089745
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author Carrizzo, Albino
Di Pardo, Alba
Maglione, Vittorio
Damato, Antonio
Amico, Enrico
Formisano, Luigi
Vecchione, Carmine
Squitieri, Ferdinando
author_facet Carrizzo, Albino
Di Pardo, Alba
Maglione, Vittorio
Damato, Antonio
Amico, Enrico
Formisano, Luigi
Vecchione, Carmine
Squitieri, Ferdinando
author_sort Carrizzo, Albino
collection PubMed
description Nitric oxide (NO) is a biologically active inorganic molecule involved in the regulation of many physiological processes, such as control of blood flow, platelet adhesion, endocrine function, neurotransmission and neuromodulation. In the present study, for the first time, we investigated the modulation of NO signaling in platelets of HD patients. We recruited 55 patients with manifest HD and 28 gender- and age-matched healthy controls. Our data demonstrated that NO-mediated vasorelaxation, when evoked by supernatant from insulin-stimulated HD platelets, gradually worsens along disease course. The defective vasorelaxation seems to stem from a faulty release of NO from platelets of HD patients and, it is associated with impairment of eNOS phosphorylation (Ser(1177)) and activity. This study provides important insights about NO metabolism in HD and raises the hypothesis that the decrease of NO in platelets of HD individuals could be a good tool for monitoring advanced stages of the disease.
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spelling pubmed-39349312014-03-04 Nitric Oxide Dysregulation in Platelets from Patients with Advanced Huntington Disease Carrizzo, Albino Di Pardo, Alba Maglione, Vittorio Damato, Antonio Amico, Enrico Formisano, Luigi Vecchione, Carmine Squitieri, Ferdinando PLoS One Research Article Nitric oxide (NO) is a biologically active inorganic molecule involved in the regulation of many physiological processes, such as control of blood flow, platelet adhesion, endocrine function, neurotransmission and neuromodulation. In the present study, for the first time, we investigated the modulation of NO signaling in platelets of HD patients. We recruited 55 patients with manifest HD and 28 gender- and age-matched healthy controls. Our data demonstrated that NO-mediated vasorelaxation, when evoked by supernatant from insulin-stimulated HD platelets, gradually worsens along disease course. The defective vasorelaxation seems to stem from a faulty release of NO from platelets of HD patients and, it is associated with impairment of eNOS phosphorylation (Ser(1177)) and activity. This study provides important insights about NO metabolism in HD and raises the hypothesis that the decrease of NO in platelets of HD individuals could be a good tool for monitoring advanced stages of the disease. Public Library of Science 2014-02-25 /pmc/articles/PMC3934931/ /pubmed/24587005 http://dx.doi.org/10.1371/journal.pone.0089745 Text en © 2014 Carrizzo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Carrizzo, Albino
Di Pardo, Alba
Maglione, Vittorio
Damato, Antonio
Amico, Enrico
Formisano, Luigi
Vecchione, Carmine
Squitieri, Ferdinando
Nitric Oxide Dysregulation in Platelets from Patients with Advanced Huntington Disease
title Nitric Oxide Dysregulation in Platelets from Patients with Advanced Huntington Disease
title_full Nitric Oxide Dysregulation in Platelets from Patients with Advanced Huntington Disease
title_fullStr Nitric Oxide Dysregulation in Platelets from Patients with Advanced Huntington Disease
title_full_unstemmed Nitric Oxide Dysregulation in Platelets from Patients with Advanced Huntington Disease
title_short Nitric Oxide Dysregulation in Platelets from Patients with Advanced Huntington Disease
title_sort nitric oxide dysregulation in platelets from patients with advanced huntington disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934931/
https://www.ncbi.nlm.nih.gov/pubmed/24587005
http://dx.doi.org/10.1371/journal.pone.0089745
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