A Porphodimethene Chemical Inhibitor of Uroporphyrinogen Decarboxylase

Uroporphyrinogen decarboxylase (UROD) catalyzes the conversion of uroporphyrinogen to coproporphyrinogen during heme biosynthesis. This enzyme was recently identified as a potential anticancer target; its inhibition leads to an increase in reactive oxygen species, likely mediated by the Fenton react...

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Detalles Bibliográficos
Autores principales: Yip, Kenneth W., Zhang, Zhan, Sakemura-Nakatsugawa, Noriko, Huang, Jui-Wen, Vu, Nhu Mai, Chiang, Yi-Kun, Lin, Chih-Lung, Kwan, Jennifer Y. Y., Yue, Shijun, Jitkova, Yulia, To, Terence, Zahedi, Payam, Pai, Emil F., Schimmer, Aaron D., Lovell, Jonathan F., Sessler, Jonathan L., Liu, Fei-Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934957/
https://www.ncbi.nlm.nih.gov/pubmed/24587102
http://dx.doi.org/10.1371/journal.pone.0089889

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