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Population-Based Incidence of Severe Acute Respiratory Virus Infections among Children Aged <5 Years in Rural Bangladesh, June–October 2010

BACKGROUND: Better understanding the etiology-specific incidence of severe acute respiratory infections (SARIs) in resource-poor, rural settings will help further develop and prioritize prevention strategies. To address this gap in knowledge, we conducted a longitudinal study to estimate the inciden...

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Autores principales: Nasreen, Sharifa, Luby, Stephen P., Brooks, W. Abdullah, Homaira, Nusrat, Mamun, Abdullah Al, Bhuiyan, Mejbah Uddin, Rahman, Mustafizur, Ahmed, Dilruba, Abedin, Jaynal, Rahman, Mahmudur, Alamgir, A. S. M., Fry, Alicia M., Streatfield, Peter Kim, Rahman, Anisur, Bresee, Joseph, Widdowson, Marc-Alain, Azziz-Baumgartner, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934972/
https://www.ncbi.nlm.nih.gov/pubmed/24587163
http://dx.doi.org/10.1371/journal.pone.0089978
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author Nasreen, Sharifa
Luby, Stephen P.
Brooks, W. Abdullah
Homaira, Nusrat
Mamun, Abdullah Al
Bhuiyan, Mejbah Uddin
Rahman, Mustafizur
Ahmed, Dilruba
Abedin, Jaynal
Rahman, Mahmudur
Alamgir, A. S. M.
Fry, Alicia M.
Streatfield, Peter Kim
Rahman, Anisur
Bresee, Joseph
Widdowson, Marc-Alain
Azziz-Baumgartner, Eduardo
author_facet Nasreen, Sharifa
Luby, Stephen P.
Brooks, W. Abdullah
Homaira, Nusrat
Mamun, Abdullah Al
Bhuiyan, Mejbah Uddin
Rahman, Mustafizur
Ahmed, Dilruba
Abedin, Jaynal
Rahman, Mahmudur
Alamgir, A. S. M.
Fry, Alicia M.
Streatfield, Peter Kim
Rahman, Anisur
Bresee, Joseph
Widdowson, Marc-Alain
Azziz-Baumgartner, Eduardo
author_sort Nasreen, Sharifa
collection PubMed
description BACKGROUND: Better understanding the etiology-specific incidence of severe acute respiratory infections (SARIs) in resource-poor, rural settings will help further develop and prioritize prevention strategies. To address this gap in knowledge, we conducted a longitudinal study to estimate the incidence of SARIs among children in rural Bangladesh. METHODS: During June through October 2010, we followed children aged <5 years in 67 villages to identify those with cough, difficulty breathing, age-specific tachypnea and/or danger signs in the community or admitted to the local hospital. A study physician collected clinical information and obtained nasopharyngeal swabs from all SARI cases and blood for bacterial culture from those hospitalized. We tested swabs for respiratory syncytial virus (RSV), influenza viruses, human metapneumoviruses, adenoviruses and human parainfluenza viruses 1–3 (HPIV) by real-time reverse transcription polymerase chain reaction. We calculated virus-specific SARI incidence by dividing the number of new illnesses by the person-time each child contributed to the study. RESULTS: We followed 12,850 children for 279,029 person-weeks (pw) and identified 141 SARI cases; 76 (54%) at their homes and 65 (46%) at the hospital. RSV was associated with 7.9 SARI hospitalizations per 100,000 pw, HPIV3 2.2 hospitalizations/100,000 pw, and influenza 1.1 hospitalizations/100,000 pw. Among non-hospitalized SARI cases, RSV was associated with 10.8 illnesses/100,000 pw, HPIV3 1.8/100,000 pw, influenza 1.4/100,000 pw, and adenoviruses 0.4/100,000 pw. CONCLUSION: Respiratory viruses, particularly RSV, were commonly associated with SARI among children. It may be useful to explore the value of investing in prevention strategies, such as handwashing and respiratory hygiene, to reduce respiratory infections among young children in such settings.
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spelling pubmed-39349722014-03-04 Population-Based Incidence of Severe Acute Respiratory Virus Infections among Children Aged <5 Years in Rural Bangladesh, June–October 2010 Nasreen, Sharifa Luby, Stephen P. Brooks, W. Abdullah Homaira, Nusrat Mamun, Abdullah Al Bhuiyan, Mejbah Uddin Rahman, Mustafizur Ahmed, Dilruba Abedin, Jaynal Rahman, Mahmudur Alamgir, A. S. M. Fry, Alicia M. Streatfield, Peter Kim Rahman, Anisur Bresee, Joseph Widdowson, Marc-Alain Azziz-Baumgartner, Eduardo PLoS One Research Article BACKGROUND: Better understanding the etiology-specific incidence of severe acute respiratory infections (SARIs) in resource-poor, rural settings will help further develop and prioritize prevention strategies. To address this gap in knowledge, we conducted a longitudinal study to estimate the incidence of SARIs among children in rural Bangladesh. METHODS: During June through October 2010, we followed children aged <5 years in 67 villages to identify those with cough, difficulty breathing, age-specific tachypnea and/or danger signs in the community or admitted to the local hospital. A study physician collected clinical information and obtained nasopharyngeal swabs from all SARI cases and blood for bacterial culture from those hospitalized. We tested swabs for respiratory syncytial virus (RSV), influenza viruses, human metapneumoviruses, adenoviruses and human parainfluenza viruses 1–3 (HPIV) by real-time reverse transcription polymerase chain reaction. We calculated virus-specific SARI incidence by dividing the number of new illnesses by the person-time each child contributed to the study. RESULTS: We followed 12,850 children for 279,029 person-weeks (pw) and identified 141 SARI cases; 76 (54%) at their homes and 65 (46%) at the hospital. RSV was associated with 7.9 SARI hospitalizations per 100,000 pw, HPIV3 2.2 hospitalizations/100,000 pw, and influenza 1.1 hospitalizations/100,000 pw. Among non-hospitalized SARI cases, RSV was associated with 10.8 illnesses/100,000 pw, HPIV3 1.8/100,000 pw, influenza 1.4/100,000 pw, and adenoviruses 0.4/100,000 pw. CONCLUSION: Respiratory viruses, particularly RSV, were commonly associated with SARI among children. It may be useful to explore the value of investing in prevention strategies, such as handwashing and respiratory hygiene, to reduce respiratory infections among young children in such settings. Public Library of Science 2014-02-25 /pmc/articles/PMC3934972/ /pubmed/24587163 http://dx.doi.org/10.1371/journal.pone.0089978 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Nasreen, Sharifa
Luby, Stephen P.
Brooks, W. Abdullah
Homaira, Nusrat
Mamun, Abdullah Al
Bhuiyan, Mejbah Uddin
Rahman, Mustafizur
Ahmed, Dilruba
Abedin, Jaynal
Rahman, Mahmudur
Alamgir, A. S. M.
Fry, Alicia M.
Streatfield, Peter Kim
Rahman, Anisur
Bresee, Joseph
Widdowson, Marc-Alain
Azziz-Baumgartner, Eduardo
Population-Based Incidence of Severe Acute Respiratory Virus Infections among Children Aged <5 Years in Rural Bangladesh, June–October 2010
title Population-Based Incidence of Severe Acute Respiratory Virus Infections among Children Aged <5 Years in Rural Bangladesh, June–October 2010
title_full Population-Based Incidence of Severe Acute Respiratory Virus Infections among Children Aged <5 Years in Rural Bangladesh, June–October 2010
title_fullStr Population-Based Incidence of Severe Acute Respiratory Virus Infections among Children Aged <5 Years in Rural Bangladesh, June–October 2010
title_full_unstemmed Population-Based Incidence of Severe Acute Respiratory Virus Infections among Children Aged <5 Years in Rural Bangladesh, June–October 2010
title_short Population-Based Incidence of Severe Acute Respiratory Virus Infections among Children Aged <5 Years in Rural Bangladesh, June–October 2010
title_sort population-based incidence of severe acute respiratory virus infections among children aged <5 years in rural bangladesh, june–october 2010
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934972/
https://www.ncbi.nlm.nih.gov/pubmed/24587163
http://dx.doi.org/10.1371/journal.pone.0089978
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