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A Novel Dried Blood Spot-LCMS Method for the Quantification of Methotrexate Polyglutamates as a Potential Marker for Methotrexate Use in Children

OBJECTIVE: Development and validation of a selective and sensitive LCMS method for the determination of methotrexate polyglutamates in dried blood spots (DBS). METHODS: DBS samples [spiked or patient samples] were prepared by applying blood to Guthrie cards which was then dried at room temperature....

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Detalles Bibliográficos
Autores principales:	Hawwa, Ahmed F., AlBawab, AbdelQader, Rooney, Madeleine, Wedderburn, Lucy R., Beresford, Michael W., McElnay, James C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3934981/ https://www.ncbi.nlm.nih.gov/pubmed/24587116 http://dx.doi.org/10.1371/journal.pone.0089908

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