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Thyroid Hormone and Seasonal Rhythmicity

Living organisms show seasonality in a wide array of functions such as reproduction, fattening, hibernation, and migration. At temperate latitudes, changes in photoperiod maintain the alignment of annual rhythms with predictable changes in the environment. The appropriate physiological response to c...

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Autores principales: Dardente, Hugues, Hazlerigg, David G., Ebling, Francis J. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935485/
https://www.ncbi.nlm.nih.gov/pubmed/24616714
http://dx.doi.org/10.3389/fendo.2014.00019
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author Dardente, Hugues
Hazlerigg, David G.
Ebling, Francis J. P.
author_facet Dardente, Hugues
Hazlerigg, David G.
Ebling, Francis J. P.
author_sort Dardente, Hugues
collection PubMed
description Living organisms show seasonality in a wide array of functions such as reproduction, fattening, hibernation, and migration. At temperate latitudes, changes in photoperiod maintain the alignment of annual rhythms with predictable changes in the environment. The appropriate physiological response to changing photoperiod in mammals requires retinal detection of light and pineal secretion of melatonin, but extraretinal detection of light occurs in birds. A common mechanism across all vertebrates is that these photoperiod-regulated systems alter hypothalamic thyroid hormone (TH) conversion. Here, we review the evidence that a circadian clock within the pars tuberalis of the adenohypophysis links photoperiod decoding to local changes of TH signaling within the medio-basal hypothalamus (MBH) through a conserved thyrotropin/deiodinase axis. We also focus on recent findings which indicate that, beyond the photoperiodic control of its conversion, TH might also be involved in longer-term timing processes of seasonal programs. Finally, we examine the potential implication of kisspeptin and RFRP3, two RF-amide peptides expressed within the MBH, in seasonal rhythmicity.
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spelling pubmed-39354852014-03-10 Thyroid Hormone and Seasonal Rhythmicity Dardente, Hugues Hazlerigg, David G. Ebling, Francis J. P. Front Endocrinol (Lausanne) Endocrinology Living organisms show seasonality in a wide array of functions such as reproduction, fattening, hibernation, and migration. At temperate latitudes, changes in photoperiod maintain the alignment of annual rhythms with predictable changes in the environment. The appropriate physiological response to changing photoperiod in mammals requires retinal detection of light and pineal secretion of melatonin, but extraretinal detection of light occurs in birds. A common mechanism across all vertebrates is that these photoperiod-regulated systems alter hypothalamic thyroid hormone (TH) conversion. Here, we review the evidence that a circadian clock within the pars tuberalis of the adenohypophysis links photoperiod decoding to local changes of TH signaling within the medio-basal hypothalamus (MBH) through a conserved thyrotropin/deiodinase axis. We also focus on recent findings which indicate that, beyond the photoperiodic control of its conversion, TH might also be involved in longer-term timing processes of seasonal programs. Finally, we examine the potential implication of kisspeptin and RFRP3, two RF-amide peptides expressed within the MBH, in seasonal rhythmicity. Frontiers Media S.A. 2014-02-26 /pmc/articles/PMC3935485/ /pubmed/24616714 http://dx.doi.org/10.3389/fendo.2014.00019 Text en Copyright © 2014 Dardente, Hazlerigg and Ebling. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Dardente, Hugues
Hazlerigg, David G.
Ebling, Francis J. P.
Thyroid Hormone and Seasonal Rhythmicity
title Thyroid Hormone and Seasonal Rhythmicity
title_full Thyroid Hormone and Seasonal Rhythmicity
title_fullStr Thyroid Hormone and Seasonal Rhythmicity
title_full_unstemmed Thyroid Hormone and Seasonal Rhythmicity
title_short Thyroid Hormone and Seasonal Rhythmicity
title_sort thyroid hormone and seasonal rhythmicity
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935485/
https://www.ncbi.nlm.nih.gov/pubmed/24616714
http://dx.doi.org/10.3389/fendo.2014.00019
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