Hypoxia Inducible Factor-1α Directly Regulates Nuclear Clusterin Transcription by Interacting with Hypoxia Response Elements in the Clusterin Promoter

Differential transcription of the clusterin (CLU) gene yields two CLU isoforms, a nuclear form (nCLU) and a secretory form (sCLU), which play crucial roles in prostate tumorigenesis. Pro-apoptotic nCLU and anti-apoptotic sCLU have opposite effects and are differentially expressed in normal and cance...

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Detalles Bibliográficos
Autores principales: Park, Jeongsook, Park, So Yun, Shin, Eunkyung, Lee, Sun Hee, Kim, Yoon Sook, Lee, Dong Hoon, Roh, Gu Seob, Kim, Hyun Joon, Kang, Sang Soo, Cho, Gyeong Jae, Jeong, Bo-Young, Kim, Hwajin, Choi, Wan Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korea Society for Molecular and Cellular Biology 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935631/
https://www.ncbi.nlm.nih.gov/pubmed/24599003
http://dx.doi.org/10.14348/molcells.2014.2349

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