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Highly Immunoreactive IgG Antibodies Directed against a Set of Twenty Human Proteins in the Sera of Patients with Amyotrophic Lateral Sclerosis Identified by Protein Array
Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disorder, is characterized by the progressive and selective loss of upper and lower motor neurons. Diagnosis of this disorder is based on clinical assessment, and the average survival time is less than 3 years. Injections...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935926/ https://www.ncbi.nlm.nih.gov/pubmed/24586901 http://dx.doi.org/10.1371/journal.pone.0089596 |
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author | May, Caroline Nordhoff, Eckhard Casjens, Swaantje Turewicz, Michael Eisenacher, Martin Gold, Ralf Brüning, Thomas Pesch, Beate Stephan, Christian Woitalla, Dirk Penke, Botond Janáky, Tamás Virók, Dezső Siklós, László Engelhardt, Jozsef I. Meyer, Helmut E. |
author_facet | May, Caroline Nordhoff, Eckhard Casjens, Swaantje Turewicz, Michael Eisenacher, Martin Gold, Ralf Brüning, Thomas Pesch, Beate Stephan, Christian Woitalla, Dirk Penke, Botond Janáky, Tamás Virók, Dezső Siklós, László Engelhardt, Jozsef I. Meyer, Helmut E. |
author_sort | May, Caroline |
collection | PubMed |
description | Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disorder, is characterized by the progressive and selective loss of upper and lower motor neurons. Diagnosis of this disorder is based on clinical assessment, and the average survival time is less than 3 years. Injections of IgG from ALS patients into mice are known to specifically mark motor neurons. Moreover, IgG has been found in upper and lower motor neurons in ALS patients. These results led us to perform a case-control study using human protein microarrays to identify the antibody profiles of serum samples from 20 ALS patients and 20 healthy controls. We demonstrated high levels of 20 IgG antibodies that distinguished the patients from the controls. These findings suggest that a panel of antibodies may serve as a potential diagnostic biomarker for ALS. |
format | Online Article Text |
id | pubmed-3935926 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39359262014-03-04 Highly Immunoreactive IgG Antibodies Directed against a Set of Twenty Human Proteins in the Sera of Patients with Amyotrophic Lateral Sclerosis Identified by Protein Array May, Caroline Nordhoff, Eckhard Casjens, Swaantje Turewicz, Michael Eisenacher, Martin Gold, Ralf Brüning, Thomas Pesch, Beate Stephan, Christian Woitalla, Dirk Penke, Botond Janáky, Tamás Virók, Dezső Siklós, László Engelhardt, Jozsef I. Meyer, Helmut E. PLoS One Research Article Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disorder, is characterized by the progressive and selective loss of upper and lower motor neurons. Diagnosis of this disorder is based on clinical assessment, and the average survival time is less than 3 years. Injections of IgG from ALS patients into mice are known to specifically mark motor neurons. Moreover, IgG has been found in upper and lower motor neurons in ALS patients. These results led us to perform a case-control study using human protein microarrays to identify the antibody profiles of serum samples from 20 ALS patients and 20 healthy controls. We demonstrated high levels of 20 IgG antibodies that distinguished the patients from the controls. These findings suggest that a panel of antibodies may serve as a potential diagnostic biomarker for ALS. Public Library of Science 2014-02-26 /pmc/articles/PMC3935926/ /pubmed/24586901 http://dx.doi.org/10.1371/journal.pone.0089596 Text en © 2014 May et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article May, Caroline Nordhoff, Eckhard Casjens, Swaantje Turewicz, Michael Eisenacher, Martin Gold, Ralf Brüning, Thomas Pesch, Beate Stephan, Christian Woitalla, Dirk Penke, Botond Janáky, Tamás Virók, Dezső Siklós, László Engelhardt, Jozsef I. Meyer, Helmut E. Highly Immunoreactive IgG Antibodies Directed against a Set of Twenty Human Proteins in the Sera of Patients with Amyotrophic Lateral Sclerosis Identified by Protein Array |
title | Highly Immunoreactive IgG Antibodies Directed against a Set of Twenty Human Proteins in the Sera of Patients with Amyotrophic Lateral Sclerosis Identified by Protein Array |
title_full | Highly Immunoreactive IgG Antibodies Directed against a Set of Twenty Human Proteins in the Sera of Patients with Amyotrophic Lateral Sclerosis Identified by Protein Array |
title_fullStr | Highly Immunoreactive IgG Antibodies Directed against a Set of Twenty Human Proteins in the Sera of Patients with Amyotrophic Lateral Sclerosis Identified by Protein Array |
title_full_unstemmed | Highly Immunoreactive IgG Antibodies Directed against a Set of Twenty Human Proteins in the Sera of Patients with Amyotrophic Lateral Sclerosis Identified by Protein Array |
title_short | Highly Immunoreactive IgG Antibodies Directed against a Set of Twenty Human Proteins in the Sera of Patients with Amyotrophic Lateral Sclerosis Identified by Protein Array |
title_sort | highly immunoreactive igg antibodies directed against a set of twenty human proteins in the sera of patients with amyotrophic lateral sclerosis identified by protein array |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3935926/ https://www.ncbi.nlm.nih.gov/pubmed/24586901 http://dx.doi.org/10.1371/journal.pone.0089596 |
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