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Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress

Defective DNA replication can result in genomic instability, cancer, and developmental defects. To understand the roles of DNA damage response (DDR) genes on carcinogenesis in mutants defective for core DNA replication components, we utilized the Mcm4(Chaos3/Chaos3) (“Chaos3”) mouse model which, by...

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Detalles Bibliográficos
Autores principales:	Wallace, Marsha D., Southard, Teresa L., Schimenti, Kerry J., Schimenti, John C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936004/ https://www.ncbi.nlm.nih.gov/pubmed/23975433 http://dx.doi.org/10.1038/onc.2013.339

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