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Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation

TFAM is a DNA binding protein that activates transcription at the two major promoters of mitochondrial DNA — the light strand promoter (LSP) and heavy strand promoter 1 (HSP1). Equally important, it coats and packages the mitochondrial genome. TFAM has been shown to impose a U-turn on LSP DNA, but w...

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Detalles Bibliográficos
Autores principales:	Ngo, Huu B., Lovely, Geoffrey A., Phillips, Rob, Chan, David C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936014/ https://www.ncbi.nlm.nih.gov/pubmed/24435062 http://dx.doi.org/10.1038/ncomms4077

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