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Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases
Thousands of bacterial phylotypes colonise the human body and the host response to this bacterial challenge greatly influences our state of health or disease. The concept of infectogenomics highlights the importance of host genetic factors in determining the composition of human microbial biofilms a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Co-Action Publishing
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936111/ https://www.ncbi.nlm.nih.gov/pubmed/24578801 http://dx.doi.org/10.3402/jom.v6.22962 |
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author | Nibali, Luigi Henderson, Brian Sadiq, Syed Tariq Donos, Nikos |
author_facet | Nibali, Luigi Henderson, Brian Sadiq, Syed Tariq Donos, Nikos |
author_sort | Nibali, Luigi |
collection | PubMed |
description | Thousands of bacterial phylotypes colonise the human body and the host response to this bacterial challenge greatly influences our state of health or disease. The concept of infectogenomics highlights the importance of host genetic factors in determining the composition of human microbial biofilms and the response to this microbial challenge. We hereby introduce the term ‘genetic dysbiosis’ to highlight the role of human genetic variants affecting microbial recognition and host response in creating an environment conducive to changes in the normal microbiota. Such changes can, in turn, predispose to, and influence, diseases such as: cancer, inflammatory bowel disease, rheumatoid arthritis, psoriasis, bacterial vaginosis and periodontitis. This review presents the state of the evidence on host genetic factors affecting dysbiosis and microbial misrecognition (i.e. an aberrant response to the normal microbiota) and highlights the need for further research in this area. |
format | Online Article Text |
id | pubmed-3936111 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Co-Action Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-39361112014-02-27 Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases Nibali, Luigi Henderson, Brian Sadiq, Syed Tariq Donos, Nikos J Oral Microbiol Review Article Thousands of bacterial phylotypes colonise the human body and the host response to this bacterial challenge greatly influences our state of health or disease. The concept of infectogenomics highlights the importance of host genetic factors in determining the composition of human microbial biofilms and the response to this microbial challenge. We hereby introduce the term ‘genetic dysbiosis’ to highlight the role of human genetic variants affecting microbial recognition and host response in creating an environment conducive to changes in the normal microbiota. Such changes can, in turn, predispose to, and influence, diseases such as: cancer, inflammatory bowel disease, rheumatoid arthritis, psoriasis, bacterial vaginosis and periodontitis. This review presents the state of the evidence on host genetic factors affecting dysbiosis and microbial misrecognition (i.e. an aberrant response to the normal microbiota) and highlights the need for further research in this area. Co-Action Publishing 2014-02-25 /pmc/articles/PMC3936111/ /pubmed/24578801 http://dx.doi.org/10.3402/jom.v6.22962 Text en © 2014 Luigi Nibali et al. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Nibali, Luigi Henderson, Brian Sadiq, Syed Tariq Donos, Nikos Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases |
title | Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases |
title_full | Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases |
title_fullStr | Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases |
title_full_unstemmed | Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases |
title_short | Genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases |
title_sort | genetic dysbiosis: the role of microbial insults in chronic inflammatory diseases |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936111/ https://www.ncbi.nlm.nih.gov/pubmed/24578801 http://dx.doi.org/10.3402/jom.v6.22962 |
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