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Evaluation of the Mutagenic Properties of Two Lignans from Acanthopanax koreanum Nakai
Acanthopanax koreanum Nakai, a well known traditional herb grown in Jeju Island, South of Korea, has been used as a tonic and sedative agent, as well as in the treatment of diabetes and immune diseases. Mutagenicity of two lignans, syringaresinol and tortoside A isolated from A. koreanum, was assess...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Toxicology
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936180/ https://www.ncbi.nlm.nih.gov/pubmed/24578798 http://dx.doi.org/10.5487/TR.2013.29.4.279 |
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author | Hong, Chang-Eui Lyu, Su-Yun |
author_facet | Hong, Chang-Eui Lyu, Su-Yun |
author_sort | Hong, Chang-Eui |
collection | PubMed |
description | Acanthopanax koreanum Nakai, a well known traditional herb grown in Jeju Island, South of Korea, has been used as a tonic and sedative agent, as well as in the treatment of diabetes and immune diseases. Mutagenicity of two lignans, syringaresinol and tortoside A isolated from A. koreanum, was assessed using Salmonella/microsome (Ames) test. Tester strains used were Salmonella typhimurium TA98, TA100, TA1535, and Escherichia coli WP2uvrA. The mutagenic activity was determined both in the absence or presence of S9 mixture. As a result, tortoside A did not cause any increase in the number of his(+) revertants in S. typhimurium and E. coli WP2uvrA strains in the presence or absence of S9 mix, compared to the controls. Similarly, low concentrations of syringaresinol (750 and 1,500 μg/plate) did not show any mutagenic properties in all bacterial strains, in the presence or absence of S9 mixture. However, in the high concentration of syringaresinol (3,000 μg/plate), the number of revertants were increased in TA1535 strains, in the absence of S9 metabolic activation. Therefore, in vivo experiments such as comet assay are needed to further determine the genotoxic/carciogenic potential of syringaresinol isolated from A. koreanum. |
format | Online Article Text |
id | pubmed-3936180 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Korean Society of Toxicology |
record_format | MEDLINE/PubMed |
spelling | pubmed-39361802014-02-26 Evaluation of the Mutagenic Properties of Two Lignans from Acanthopanax koreanum Nakai Hong, Chang-Eui Lyu, Su-Yun Toxicol Res Articles Acanthopanax koreanum Nakai, a well known traditional herb grown in Jeju Island, South of Korea, has been used as a tonic and sedative agent, as well as in the treatment of diabetes and immune diseases. Mutagenicity of two lignans, syringaresinol and tortoside A isolated from A. koreanum, was assessed using Salmonella/microsome (Ames) test. Tester strains used were Salmonella typhimurium TA98, TA100, TA1535, and Escherichia coli WP2uvrA. The mutagenic activity was determined both in the absence or presence of S9 mixture. As a result, tortoside A did not cause any increase in the number of his(+) revertants in S. typhimurium and E. coli WP2uvrA strains in the presence or absence of S9 mix, compared to the controls. Similarly, low concentrations of syringaresinol (750 and 1,500 μg/plate) did not show any mutagenic properties in all bacterial strains, in the presence or absence of S9 mixture. However, in the high concentration of syringaresinol (3,000 μg/plate), the number of revertants were increased in TA1535 strains, in the absence of S9 metabolic activation. Therefore, in vivo experiments such as comet assay are needed to further determine the genotoxic/carciogenic potential of syringaresinol isolated from A. koreanum. The Korean Society of Toxicology 2013-12-31 /pmc/articles/PMC3936180/ /pubmed/24578798 http://dx.doi.org/10.5487/TR.2013.29.4.279 Text en Copyright ©2013, The Korean Society of Toxicology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Hong, Chang-Eui Lyu, Su-Yun Evaluation of the Mutagenic Properties of Two Lignans from Acanthopanax koreanum Nakai |
title | Evaluation of the Mutagenic Properties of Two Lignans from Acanthopanax koreanum Nakai |
title_full | Evaluation of the Mutagenic Properties of Two Lignans from Acanthopanax koreanum Nakai |
title_fullStr | Evaluation of the Mutagenic Properties of Two Lignans from Acanthopanax koreanum Nakai |
title_full_unstemmed | Evaluation of the Mutagenic Properties of Two Lignans from Acanthopanax koreanum Nakai |
title_short | Evaluation of the Mutagenic Properties of Two Lignans from Acanthopanax koreanum Nakai |
title_sort | evaluation of the mutagenic properties of two lignans from acanthopanax koreanum nakai |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936180/ https://www.ncbi.nlm.nih.gov/pubmed/24578798 http://dx.doi.org/10.5487/TR.2013.29.4.279 |
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