An acute phase protein ready to go therapeutic for sepsis

The so-called Acute Phase Response (APR) begins between 12 and 48 h after the initiation of inflammation. This conserved response mainly involves the production of a set of Acute Phase Proteins (APPs) and the downregulation of other proteins (negative APPs) by hepatocytes. Although the precise ident...

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Detalles Bibliográficos
Autores principales: Vandevyver, Sofie, Dejager, Lien, Vandenbroucke, Roosmarijn E, Libert, Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell 2014
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936485/
https://www.ncbi.nlm.nih.gov/pubmed/24408964
http://dx.doi.org/10.1002/emmm.201303524
Descripción
Sumario:The so-called Acute Phase Response (APR) begins between 12 and 48 h after the initiation of inflammation. This conserved response mainly involves the production of a set of Acute Phase Proteins (APPs) and the downregulation of other proteins (negative APPs) by hepatocytes. Although the precise identity of the APPs may differ between species, some APPs are common in all mammals.

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