Cargando…

Single Nucleotide Polymorphisms of Toll-Like Receptor 7 and Toll-Like Receptor 9 in Hepatitis C Virus Infection Patients from Central China

PURPOSE: To analyze the correlation of polymorphisms of toll-like receptor 7 (TLR7) (rs179009) and toll-like receptor 9 (TLR9) (rs187084) in hepatitis C virus (HCV) infections in the Han population. MATERIALS AND METHODS: The genotypes of TLR7IVS2-151 in HCV infection were detected by Sanger sequenc...

Descripción completa

Detalles Bibliográficos
Autores principales: Wei, Xin-su, Wei, Chuan-dong, Tong, Yong-qing, Zhu, Cheng-liang, Zhang, Ping-an
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936647/
https://www.ncbi.nlm.nih.gov/pubmed/24532514
http://dx.doi.org/10.3349/ymj.2014.55.2.428
_version_ 1782305338339360768
author Wei, Xin-su
Wei, Chuan-dong
Tong, Yong-qing
Zhu, Cheng-liang
Zhang, Ping-an
author_facet Wei, Xin-su
Wei, Chuan-dong
Tong, Yong-qing
Zhu, Cheng-liang
Zhang, Ping-an
author_sort Wei, Xin-su
collection PubMed
description PURPOSE: To analyze the correlation of polymorphisms of toll-like receptor 7 (TLR7) (rs179009) and toll-like receptor 9 (TLR9) (rs187084) in hepatitis C virus (HCV) infections in the Han population. MATERIALS AND METHODS: The genotypes of TLR7IVS2-151 in HCV infection were detected by Sanger sequencing using polymerase chain reaction-restriction fragment length polymorphism to determine the TLR9 T-1486C single nucleotide polymorphisms (SNP) for all enrolled patients. RESULTS: We found no significant difference between males with spontaneous clearance of HCV versus those chronically infected [χ(2)=2.71, p=0.10, odd ratios (OR)=0.58, 95% confidence interval (CI) 0.31-1.11]. However, significant differences were found for the distribution of TLR7 (rs179009) in females (χ(2)=9.46, p=0.01). In females, a significant difference was also found between chronic hepatitis C and those with spontaneous clearance of HCV in terms of TLR7 IVS2-151G/A allele frequencies (χ(2)=9.50, p=0.00, OR=0.46, 95% CI 0.28-0.75). In HCV-infected patients, no significant association was found between the frequency of TLR9 genotypes and alleles. CONCLUSION: The site of TLR7 IVS2-151 (rs179009) G/A may be a factor for susceptibility of chronic HCV in the female Han population. TLR9T-1486C (rs18084) SNP may not play a major role in HCV infection. However, individual risk profiles for HCV infection did vary by sex and this relationship should be further investigated.
format Online
Article
Text
id pubmed-3936647
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Yonsei University College of Medicine
record_format MEDLINE/PubMed
spelling pubmed-39366472014-03-04 Single Nucleotide Polymorphisms of Toll-Like Receptor 7 and Toll-Like Receptor 9 in Hepatitis C Virus Infection Patients from Central China Wei, Xin-su Wei, Chuan-dong Tong, Yong-qing Zhu, Cheng-liang Zhang, Ping-an Yonsei Med J Original Article PURPOSE: To analyze the correlation of polymorphisms of toll-like receptor 7 (TLR7) (rs179009) and toll-like receptor 9 (TLR9) (rs187084) in hepatitis C virus (HCV) infections in the Han population. MATERIALS AND METHODS: The genotypes of TLR7IVS2-151 in HCV infection were detected by Sanger sequencing using polymerase chain reaction-restriction fragment length polymorphism to determine the TLR9 T-1486C single nucleotide polymorphisms (SNP) for all enrolled patients. RESULTS: We found no significant difference between males with spontaneous clearance of HCV versus those chronically infected [χ(2)=2.71, p=0.10, odd ratios (OR)=0.58, 95% confidence interval (CI) 0.31-1.11]. However, significant differences were found for the distribution of TLR7 (rs179009) in females (χ(2)=9.46, p=0.01). In females, a significant difference was also found between chronic hepatitis C and those with spontaneous clearance of HCV in terms of TLR7 IVS2-151G/A allele frequencies (χ(2)=9.50, p=0.00, OR=0.46, 95% CI 0.28-0.75). In HCV-infected patients, no significant association was found between the frequency of TLR9 genotypes and alleles. CONCLUSION: The site of TLR7 IVS2-151 (rs179009) G/A may be a factor for susceptibility of chronic HCV in the female Han population. TLR9T-1486C (rs18084) SNP may not play a major role in HCV infection. However, individual risk profiles for HCV infection did vary by sex and this relationship should be further investigated. Yonsei University College of Medicine 2014-03-01 2014-02-10 /pmc/articles/PMC3936647/ /pubmed/24532514 http://dx.doi.org/10.3349/ymj.2014.55.2.428 Text en © Copyright: Yonsei University College of Medicine 2014 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Wei, Xin-su
Wei, Chuan-dong
Tong, Yong-qing
Zhu, Cheng-liang
Zhang, Ping-an
Single Nucleotide Polymorphisms of Toll-Like Receptor 7 and Toll-Like Receptor 9 in Hepatitis C Virus Infection Patients from Central China
title Single Nucleotide Polymorphisms of Toll-Like Receptor 7 and Toll-Like Receptor 9 in Hepatitis C Virus Infection Patients from Central China
title_full Single Nucleotide Polymorphisms of Toll-Like Receptor 7 and Toll-Like Receptor 9 in Hepatitis C Virus Infection Patients from Central China
title_fullStr Single Nucleotide Polymorphisms of Toll-Like Receptor 7 and Toll-Like Receptor 9 in Hepatitis C Virus Infection Patients from Central China
title_full_unstemmed Single Nucleotide Polymorphisms of Toll-Like Receptor 7 and Toll-Like Receptor 9 in Hepatitis C Virus Infection Patients from Central China
title_short Single Nucleotide Polymorphisms of Toll-Like Receptor 7 and Toll-Like Receptor 9 in Hepatitis C Virus Infection Patients from Central China
title_sort single nucleotide polymorphisms of toll-like receptor 7 and toll-like receptor 9 in hepatitis c virus infection patients from central china
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936647/
https://www.ncbi.nlm.nih.gov/pubmed/24532514
http://dx.doi.org/10.3349/ymj.2014.55.2.428
work_keys_str_mv AT weixinsu singlenucleotidepolymorphismsoftolllikereceptor7andtolllikereceptor9inhepatitiscvirusinfectionpatientsfromcentralchina
AT weichuandong singlenucleotidepolymorphismsoftolllikereceptor7andtolllikereceptor9inhepatitiscvirusinfectionpatientsfromcentralchina
AT tongyongqing singlenucleotidepolymorphismsoftolllikereceptor7andtolllikereceptor9inhepatitiscvirusinfectionpatientsfromcentralchina
AT zhuchengliang singlenucleotidepolymorphismsoftolllikereceptor7andtolllikereceptor9inhepatitiscvirusinfectionpatientsfromcentralchina
AT zhangpingan singlenucleotidepolymorphismsoftolllikereceptor7andtolllikereceptor9inhepatitiscvirusinfectionpatientsfromcentralchina