TRF1 and TRF2 use different mechanisms to find telomeric DNA but share a novel mechanism to search for protein partners at telomeres

Human telomeres are maintained by the shelterin protein complex in which TRF1 and TRF2 bind directly to duplex telomeric DNA. How these proteins find telomeric sequences among a genome of billions of base pairs and how they find protein partners to form the shelterin complex remains uncertain. Using...

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Detalles Bibliográficos
Autores principales: Lin, Jiangguo, Countryman, Preston, Buncher, Noah, Kaur, Parminder, E, Longjiang, Zhang, Yiyun, Gibson, Greg, You, Changjiang, Watkins, Simon C., Piehler, Jacob, Opresko, Patricia L., Kad, Neil M., Wang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936710/
https://www.ncbi.nlm.nih.gov/pubmed/24271387
http://dx.doi.org/10.1093/nar/gkt1132

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