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Structural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2

Nonsense-mediated decay (NMD) is a eukaryotic quality control pathway, involving conserved proteins UPF1, UPF2 and UPF3b, which detects and degrades mRNAs with premature stop codons. Human UPF2 comprises three tandem MIF4G domains and a C-terminal UPF1 binding region. MIF4G-3 binds UPF3b, but the sp...

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Detalles Bibliográficos
Autores principales:	Clerici, Marcello, Deniaud, Aurélien, Boehm, Volker, Gehring, Niels H., Schaffitzel, Christiane, Cusack, Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	RNA
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936715/ https://www.ncbi.nlm.nih.gov/pubmed/24271394 http://dx.doi.org/10.1093/nar/gkt1197

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