Cargando…

Structural mechanism of transcription regulation of the Staphylococcus aureus multidrug efflux operon mepRA by the MarR family repressor MepR

The multidrug efflux pump MepA is a major contributor to multidrug resistance in Staphylococcus aureus. MepR, a member of the multiple antibiotic resistance regulator (MarR) family, represses mepA and its own gene. Here, we report the structure of a MepR–mepR operator complex. Structural comparison...

Descripción completa

Detalles Bibliográficos
Autores principales:	Birukou, Ivan, Seo, Susan M., Schindler, Bryan D., Kaatz, Glenn W., Brennan, Richard G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936728/ https://www.ncbi.nlm.nih.gov/pubmed/24293644 http://dx.doi.org/10.1093/nar/gkt1215

Ejemplares similares

Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA
por: Kumaraswami, Muthiah, et al.
Publicado: (2009)

The Molecular Mechanisms of Allosteric Mutations Impairing MepR Repressor Function in Multidrug-Resistant Strains of Staphylococcus aureus
por: Birukou, Ivan, et al.
Publicado: (2013)

Structural insights into the redox-switch mechanism of the MarR/DUF24-type regulator HypR
por: Palm, Gottfried J., et al.
Publicado: (2012)

The structure of NMB1585, a MarR-family regulator from Neisseria meningitidis
por: Nichols, Charles E., et al.
Publicado: (2009)

Biophysical and structural characterization of a zinc-responsive repressor of the MarR superfamily
por: Varela, Paloma Fernández, et al.
Publicado: (2019)

The MarR-Type Repressor MhqR Confers Quinone and Antimicrobial Resistance in Staphylococcus aureus
por: Fritsch, Verena Nadin, et al.
Publicado: (2019)

TcaR–ssDNA complex crystal structure reveals new DNA binding mechanism of the MarR family proteins
por: Chang, Yu-Ming, et al.
Publicado: (2014)

ST1710–DNA complex crystal structure reveals the DNA binding mechanism of the MarR family of regulators
por: Kumarevel, Thirumananseri, et al.
Publicado: (2009)

Study of PcaV from Streptomyces coelicolor yields new insights into ligand-responsive MarR family transcription factors
por: Davis, Jennifer R., et al.
Publicado: (2013)

Revit MEP 2018 : curso práctico /
por: Peña Arribas, Luis Carlos de la
Publicado: (2017)

Tigecycline Resistance-Associated Mutations in the MepA Efflux Pump in Staphylococcus aureus
por: Huang, Honghao, et al.
Publicado: (2023)

Distinct Amino Acid Availability-Dependent Regulatory Mechanisms of MepS and MepM Levels in Escherichia coli
por: Kim, Yung Jae, et al.
Publicado: (2021)

Mastering Autodesk Revit MEP 2015
por: Bokmiller, Don, et al.
Publicado: (2014)

Mastering Autodesk Revit MEP 2013
por: Bokmiller, Don, et al.
Publicado: (2012)

Mastering Autodesk Revit MEP 2011
por: Bokmiller, Don, et al.
Publicado: (2010)

Mastering Autodesk Revit MEP 2012
por: Bokmiller, Don, et al.
Publicado: (2011)

Mastering Autodesk Revit MEP 2014
por: Bokmiller, Don, et al.
Publicado: (2013)

Mastering autodesk revit MEP 2016
por: Whitbread, Simon
Publicado: (2015)

MEPs approve plans for European CDC
por: Rogers, Arthur
Publicado: (2004)

Regulation of Metabolic Pathways by MarR Family Transcription Factors
por: Grove, Anne
Publicado: (2017)

Restoring colistin sensitivity in colistin-resistant E. coli: Combinatorial use of MarR inhibitor with efflux pump inhibitor
por: Sundaramoorthy, Niranjana Sri, et al.
Publicado: (2019)

Chalcones Isolated from Arrabidaea brachypoda Flowers as Inhibitors of NorA and MepA Multidrug Efflux Pumps of Staphylococcus aureus
por: Rezende-Júnior, Luís Mário, et al.
Publicado: (2020)

The MEPS server for identifying protein conformational epitopes
por: Castrignanò, Tiziana, et al.
Publicado: (2007)

Linux implementation of the MEP protocol for the LHCb experiment
por: Olejnik, L, et al.
Publicado: (2010)

CtcS, a MarR family regulator, regulates chlortetracycline biosynthesis
por: Kong, Lingxin, et al.
Publicado: (2019)

Diverse MarR bacterial regulators of auxin catabolism in the plant microbiome
por: Conway, Jonathan M., et al.
Publicado: (2022)

MarR Family Transcriptional Regulators and Their Roles in Plant-Interacting Bacteria
por: Nazaret, Fanny, et al.
Publicado: (2023)

Metarhizium robertsii ammonium permeases (MepC and Mep2) contribute to rhizoplane colonization and modulates the transfer of insect derived nitrogen to plants
por: Moonjely, Soumya, et al.
Publicado: (2019)

Contributions of mutations in acrR and marR genes to organic solvent tolerance in Escherichia coli
por: Watanabe, Rei, et al.
Publicado: (2012)

Inactivation of MarR gene homologs increases susceptibility to antimicrobials in Bacteroides fragilis
por: Silva, Clara Maria Guimarães, et al.
Publicado: (2017)

The Multifaceted MEP Pathway: Towards New Therapeutic Perspectives
por: Allamand, Alizée, et al.
Publicado: (2023)

Two MarR-Type Repressors Balance Precursor Uptake and Glycine Betaine Synthesis in Bacillus subtilis to Provide Cytoprotection Against Sustained Osmotic Stress
por: Warmbold, Bianca, et al.
Publicado: (2020)

Coexistence of Ammonium Transporter and Channel Mechanisms in Amt-Mep-Rh Twin-His Variants Impairs the Filamentation Signaling Capacity of Fungal Mep2 Transceptors
por: Williamson, Gordon, et al.
Publicado: (2022)

Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli
por: Praski Alzrigat, Lisa, et al.
Publicado: (2017)

Crystal structure of the multiple antibiotic resistance regulator MarR from Clostridium difficile
por: Peng, J. W., et al.
Publicado: (2017)

Structural analysis of the regulatory mechanism of MarR protein Rv2887 in M. tuberculosis
por: Gao, Yun-Rong, et al.
Publicado: (2017)

The MarR-Type Regulator PA3458 Is Involved in Osmoadaptation Control in Pseudomonas aeruginosa
por: Kotecka, Karolina, et al.
Publicado: (2021)

Reconciling Medical Expenditure Estimates from the MEPS and the NHA, 1996
por: Selden, Thomas M., et al.
Publicado: (2001)

Reconciling Medical Expenditure Estimates from the MEPS and NHEA, 2002
por: Sing, Merrile, et al.
Publicado: (2006)

Reconstruction and Evaluation of the Synthetic Bacterial MEP Pathway in Saccharomyces cerevisiae
por: Partow, Siavash, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_ugg9fqir3h5v7li1e91hc1a229