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Adaptation of the Haloarcula hispanica CRISPR-Cas system to a purified virus strictly requires a priming process
The clustered regularly interspaced short palindromic repeat (CRISPR)-Cas system mediates adaptive immunity against foreign nucleic acids in prokaryotes. However, efficient adaptation of a native CRISPR to purified viruses has only been observed for the type II-A system from a Streptococcus thermoph...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936756/ https://www.ncbi.nlm.nih.gov/pubmed/24265226 http://dx.doi.org/10.1093/nar/gkt1154 |