Cargando…

The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation

The replicative mini-chromosome-maintenance 2–7 (MCM2-7) helicase is loaded in Saccharomyces cerevisiae and other eukaryotes as a head-to-head double-hexamer around origin DNA. At first, ORC/Cdc6 recruits with the help of Cdt1 a single MCM2-7 hexamer to form an ‘initial’ ORC/Cdc6/Cdt1/MCM2-7 complex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Evrin, Cecile, Fernández-Cid, Alejandra, Riera, Alberto, Zech, Juergen, Clarke, Pippa, Herrera, M. Carmen, Tognetti, Silvia, Lurz, Rudi, Speck, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936773/ https://www.ncbi.nlm.nih.gov/pubmed/24234446 http://dx.doi.org/10.1093/nar/gkt1148

Ejemplares similares

In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2–7 hexamer dimerization
por: Evrin, Cecile, et al.
Publicado: (2013)

Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2–7 complex
por: Kundu, Lena R., et al.
Publicado: (2010)

The ORC/Cdc6/MCM2–7 complex, a new power player for regulated helicase loading
por: Riera, Alberto, et al.
Publicado: (2013)

The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication
por: Aparicio, Tomás, et al.
Publicado: (2009)

The Saccharomyces cerevisiae Mcm6/2 and Mcm5/3 ATPase active sites contribute to the function of the putative Mcm2-7 ‘gate’
por: Bochman, Matthew L., et al.
Publicado: (2010)

Phosphorylation of Mcm2 modulates Mcm2–7 activity and affects the cell’s response to DNA damage
por: Stead, Brent E., et al.
Publicado: (2011)

Potent DNA strand annealing activity associated with mouse Mcm2∼7 heterohexameric complex
por: You, Zhiying, et al.
Publicado: (2017)

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA
por: Sun, Jingchuan, et al.
Publicado: (2013)

A reconstituted system reveals how activating and inhibitory interactions control DDK dependent assembly of the eukaryotic replicative helicase
por: Herrera, M. Carmen, et al.
Publicado: (2015)

Post-transcriptional homeostasis and regulation of MCM2–7 in mammalian cells
por: Chuang, Chen-Hua, et al.
Publicado: (2012)

An intact Mcm10 coiled-coil interaction surface is important for origin melting, helicase assembly and the recruitment of Pol-α to Mcm2–7
por: Perez-Arnaiz, Patricia, et al.
Publicado: (2017)

High-resolution analysis of four efficient yeast replication origins reveals new insights into the ORC and putative MCM binding elements
por: Chang, FuJung, et al.
Publicado: (2011)

Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1
por: Yuan, Zuanning, et al.
Publicado: (2017)

Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation
por: Fatoba, Samuel T., et al.
Publicado: (2013)

Activity, substrate preference and structure of the HsMCM8/9 helicase
por: McKinzey, David R, et al.
Publicado: (2023)

High-temperature single-molecule kinetic analysis of thermophilic archaeal MCM helicases
por: Schermerhorn, Kelly M., et al.
Publicado: (2016)

The importance of nuclear RAGE–Mcm2 axis in diabetes or cancer-associated replication stress
por: Han, Zhe, et al.
Publicado: (2023)

An Orc1/Cdc6 ortholog functions as a key regulator in the DNA damage response in Archaea
por: Sun, Mengmeng, et al.
Publicado: (2018)

CRL4–DDB1–VPRBP ubiquitin ligase mediates the stress triggered proteolysis of Mcm10
por: Kaur, Manpreet, et al.
Publicado: (2012)

The N-terminus of Mcm10 is important for interaction with the 9-1-1 clamp and in resistance to DNA damage
por: Alver, Robert C., et al.
Publicado: (2014)

Novel roles of HP1a and Mcm10 in DNA replication, genome maintenance and photoreceptor cell differentiation
por: Vo, Nicole, et al.
Publicado: (2017)

Structural and mechanistic insights into Mcm2–7 double-hexamer assembly and function
por: Sun, Jingchuan, et al.
Publicado: (2014)

Mcm2, but Not Rpa, Is a Component of the Mammalian Early G1-Phase Prereplication Complex
por: Dimitrova, Daniela S., et al.
Publicado: (1999)

Steric exclusion and wrapping of the excluded DNA strand occurs along discrete external binding paths during MCM helicase unwinding
por: Graham, Brian W., et al.
Publicado: (2011)

A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes
por: Shastri, Vivek M, et al.
Publicado: (2021)

Seeing is believing: The MCM2–7 helicase trapped in complex with its DNA loader
por: Riera, Alberto, et al.
Publicado: (2013)

Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture
por: Sugimoto, Nozomi, et al.
Publicado: (2015)

Molecular determinants of origin discrimination by Orc1 initiators in archaea
por: Dueber, Erin C., et al.
Publicado: (2011)

TRF2-mediated ORC recruitment underlies telomere stability upon DNA replication stress
por: Higa, Mitsunori, et al.
Publicado: (2021)

O-GlcNAc transferase associates with the MCM2–7 complex and its silencing destabilizes MCM–MCM interactions
por: Leturcq, Maïté, et al.
Publicado: (2018)

Combinatorial recognition of a complex telomere repeat sequence by the Candida parapsilosis Cdc13AB heterodimer
por: Steinberg-Neifach, Olga, et al.
Publicado: (2015)

The telomeric Cdc13–Stn1–Ten1 complex regulates RNA polymerase II transcription
por: Calvo, Olga, et al.
Publicado: (2019)

A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2–7 onto DNA
por: Samel, Stefan A., et al.
Publicado: (2014)

Helicobacter pylori oriC—the first bipartite origin of chromosome replication in Gram-negative bacteria
por: Donczew, Rafał, et al.
Publicado: (2012)

Crosstalk between vertical and horizontal gene transfer: plasmid replication control by a conjugative relaxase
por: Lorenzo-Díaz, Fabián, et al.
Publicado: (2017)

Genomewide and biochemical analyses of DNA-binding activity of Cdc6/Orc1 and Mcm proteins in Pyrococcus sp.
por: Matsunaga, Fujihiko, et al.
Publicado: (2007)

Juvenile Hormone-Receptor Complex Acts on Mcm4 and Mcm7 to Promote Polyploidy and Vitellogenesis in the Migratory Locust
por: Guo, Wei, et al.
Publicado: (2014)

The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer
por: Saleh, Almutasem, et al.
Publicado: (2022)

Nuclear import of Cdc13 limits chromosomal capping
por: Mersaoui, Sofiane Y, et al.
Publicado: (2018)

Plasmid replication based on the T7 origin of replication requires a T7 RNAP variant and inactivation of ribonuclease H
por: Becker, Katja, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_36g2a41e9jkrf1c20rhu3oll2q