Suppressing aberrant GluN3A expression rescues NMDA receptor dysfunction, synapse loss and motor and cognitive decline in Huntington's disease models

Huntington's disease is caused by an expanded polyglutamine repeat in huntingtin (Htt), but the pathophysiological sequence of events that trigger synaptic failure and neuronal loss are not fully understood. Alterations in NMDA-type glutamate receptors (NMDARs) have been implicated, yet it rema...

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Detalles Bibliográficos
Autores principales: Marco, Sonia, Giralt, Albert, Petrovic, Milos M., Pouladi, Mahmoud A., Martínez-Turrillas, Rebeca, Martínez-Hernández, José, Kaltenbach, Linda S., Torres-Peraza, Jesús, Graham, Rona K., Watanabe, Masahiko, Luján, Rafael, Nakanishi, Nobuki, Lipton, Stuart A., Lo, Donald C., Hayden, Michael R., Alberch, Jordi, Wesseling, John F., Pérez-Otaño, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936794/
https://www.ncbi.nlm.nih.gov/pubmed/23852340
http://dx.doi.org/10.1038/nm.3246

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