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Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation

BACKGROUND: DNA methyltransferase 1 (DNMT1) plays a critical role in breast cancer progression. However, the epigenetic mechanism regulating DNMT1 expression remains largely unknown. METHODS: Epigenetic regulation of DNMT1 was assessed in 85 invasive ductal carcinomas from BRCA1 mutation carriers. A...

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Detalles Bibliográficos
Autores principales:	Li, Da, Bi, Fang-Fang, Cao, Ji-Min, Cao, Chen, Liu, Bo, Yang, Qing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936805/ https://www.ncbi.nlm.nih.gov/pubmed/24502362 http://dx.doi.org/10.1186/1476-4598-13-26

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