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Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients
BACKGROUND: Tumor Associated Antigens are characterized by spontaneous immune response in cancer patients as a consequence of overexpression and epitope-presentation on MHC class I/II machinery. Matrix Metalloprotease 11 (MMP11) expression has been associated with poor prognosis for several cancer t...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936832/ https://www.ncbi.nlm.nih.gov/pubmed/24564996 http://dx.doi.org/10.1186/1479-5876-12-54 |
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author | Roscilli, Giuseppe Cappelletti, Manuela De Vitis, Claudia Ciliberto, Gennaro Di Napoli, Arianna Ruco, Luigi Mancini, Rita Aurisicchio, Luigi |
author_facet | Roscilli, Giuseppe Cappelletti, Manuela De Vitis, Claudia Ciliberto, Gennaro Di Napoli, Arianna Ruco, Luigi Mancini, Rita Aurisicchio, Luigi |
author_sort | Roscilli, Giuseppe |
collection | PubMed |
description | BACKGROUND: Tumor Associated Antigens are characterized by spontaneous immune response in cancer patients as a consequence of overexpression and epitope-presentation on MHC class I/II machinery. Matrix Metalloprotease 11 (MMP11) expression has been associated with poor prognosis for several cancer types, including breast and prostate cancer. METHODS: MMP11 expression was determined by immunoistochemistry in breast and prostate cancer samples. Circulating MMP11 protein as well as the spontaneous immune responses against MMP11 were analyzed in a set of breast and prostate cancer patients. RESULTS: In plasma samples MMP11 protein was present in 5/13 breast cancer patients and in 1/12 prostate cancer patients. An antibody response was observed in 7/13 breast cancer patients and in 3/12 prostate cancer patients. CONCLUSIONS: These findings further suggest MMP11 as a promising biomarker for these tumor types and a suitable target for cancer immunotherapy strategies. |
format | Online Article Text |
id | pubmed-3936832 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39368322014-02-28 Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients Roscilli, Giuseppe Cappelletti, Manuela De Vitis, Claudia Ciliberto, Gennaro Di Napoli, Arianna Ruco, Luigi Mancini, Rita Aurisicchio, Luigi J Transl Med Research BACKGROUND: Tumor Associated Antigens are characterized by spontaneous immune response in cancer patients as a consequence of overexpression and epitope-presentation on MHC class I/II machinery. Matrix Metalloprotease 11 (MMP11) expression has been associated with poor prognosis for several cancer types, including breast and prostate cancer. METHODS: MMP11 expression was determined by immunoistochemistry in breast and prostate cancer samples. Circulating MMP11 protein as well as the spontaneous immune responses against MMP11 were analyzed in a set of breast and prostate cancer patients. RESULTS: In plasma samples MMP11 protein was present in 5/13 breast cancer patients and in 1/12 prostate cancer patients. An antibody response was observed in 7/13 breast cancer patients and in 3/12 prostate cancer patients. CONCLUSIONS: These findings further suggest MMP11 as a promising biomarker for these tumor types and a suitable target for cancer immunotherapy strategies. BioMed Central 2014-02-24 /pmc/articles/PMC3936832/ /pubmed/24564996 http://dx.doi.org/10.1186/1479-5876-12-54 Text en Copyright © 2014 Roscilli et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
spellingShingle | Research Roscilli, Giuseppe Cappelletti, Manuela De Vitis, Claudia Ciliberto, Gennaro Di Napoli, Arianna Ruco, Luigi Mancini, Rita Aurisicchio, Luigi Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients |
title | Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients |
title_full | Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients |
title_fullStr | Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients |
title_full_unstemmed | Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients |
title_short | Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients |
title_sort | circulating mmp11 and specific antibody immune response in breast and prostate cancer patients |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936832/ https://www.ncbi.nlm.nih.gov/pubmed/24564996 http://dx.doi.org/10.1186/1479-5876-12-54 |
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