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Differences in virulence of pneumolysin and autolysin mutants constructed by insertion duplication mutagenesis and in-frame deletion in Streptococcus pneumoniae

BACKGROUND: Insertion duplication mutagenesis (IDM) and in-frame deletion (IFD) are common techniques for studying gene function, and have been applied to pneumolysin (ply), a virulence gene in Streptococcus pneumoniae (D39). Discrepancies in virulence between the two techniques were observed in bot...

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Detalles Bibliográficos
Autores principales:	Liu, Esther Yip-Mei, Chang, Feng-Yee, Chang, Jen-Chang, Fung, Chang-Phone
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936844/ https://www.ncbi.nlm.nih.gov/pubmed/24558977 http://dx.doi.org/10.1186/1472-6750-14-16

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