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Contribution of anterior cingulate cortex and descending pain inhibitory system to analgesic effect of lemon odor in mice
BACKGROUND: Affections are thought to regulate pain perception through the descending pain inhibitory system in the central nervous system. In this study, we examined in mice the affective change by inhalation of the lemon oil, which is well used for aromatherapy, and the effect of lemon odor on pai...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936890/ https://www.ncbi.nlm.nih.gov/pubmed/24555533 http://dx.doi.org/10.1186/1744-8069-10-14 |
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author | Ikeda, Hiroshi Takasu, Syuntaro Murase, Kazuyuki |
author_facet | Ikeda, Hiroshi Takasu, Syuntaro Murase, Kazuyuki |
author_sort | Ikeda, Hiroshi |
collection | PubMed |
description | BACKGROUND: Affections are thought to regulate pain perception through the descending pain inhibitory system in the central nervous system. In this study, we examined in mice the affective change by inhalation of the lemon oil, which is well used for aromatherapy, and the effect of lemon odor on pain sensation. We also examined the anterior cingulate cortex (ACC) and descending pain inhibitory system to such regulation of pain. RESULTS: In the elevated plus maze, the time spent in the open arms was increased by inhalation of lemon oil. The pain behavior induced by injection of formalin into the hind paw was decreased. By inhalation of lemon oil, the number of c-Fos expression by formalin injection was significantly increased in the ACC, periaqueductal grey (PAG), nucleu raphe magnus (NRM) and locus ceruleus, and decreased in the spinal dorsal horn (SDH). The destruction of the ACC with ibotenic acid led to prevent the decrease of formalin-evoked nocifensive behavior in mice exposed to lemon oil. In these mice, the change of formalin-induced c-Fos expression in the ACC, lateral PAG, NRM and SDH by lemon odor was also prevented. Antagonize of dopamine D1 receptor in the ACC prevented to the analgesic effect of lemon oil. CONCLUSIONS: These results suggest that the analgesic effect of lemon oil is induced by dopamine-related activation of ACC and the descending pain inhibitory system. |
format | Online Article Text |
id | pubmed-3936890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39368902014-02-28 Contribution of anterior cingulate cortex and descending pain inhibitory system to analgesic effect of lemon odor in mice Ikeda, Hiroshi Takasu, Syuntaro Murase, Kazuyuki Mol Pain Research BACKGROUND: Affections are thought to regulate pain perception through the descending pain inhibitory system in the central nervous system. In this study, we examined in mice the affective change by inhalation of the lemon oil, which is well used for aromatherapy, and the effect of lemon odor on pain sensation. We also examined the anterior cingulate cortex (ACC) and descending pain inhibitory system to such regulation of pain. RESULTS: In the elevated plus maze, the time spent in the open arms was increased by inhalation of lemon oil. The pain behavior induced by injection of formalin into the hind paw was decreased. By inhalation of lemon oil, the number of c-Fos expression by formalin injection was significantly increased in the ACC, periaqueductal grey (PAG), nucleu raphe magnus (NRM) and locus ceruleus, and decreased in the spinal dorsal horn (SDH). The destruction of the ACC with ibotenic acid led to prevent the decrease of formalin-evoked nocifensive behavior in mice exposed to lemon oil. In these mice, the change of formalin-induced c-Fos expression in the ACC, lateral PAG, NRM and SDH by lemon odor was also prevented. Antagonize of dopamine D1 receptor in the ACC prevented to the analgesic effect of lemon oil. CONCLUSIONS: These results suggest that the analgesic effect of lemon oil is induced by dopamine-related activation of ACC and the descending pain inhibitory system. BioMed Central 2014-02-20 /pmc/articles/PMC3936890/ /pubmed/24555533 http://dx.doi.org/10.1186/1744-8069-10-14 Text en Copyright © 2014 Ikeda et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
spellingShingle | Research Ikeda, Hiroshi Takasu, Syuntaro Murase, Kazuyuki Contribution of anterior cingulate cortex and descending pain inhibitory system to analgesic effect of lemon odor in mice |
title | Contribution of anterior cingulate cortex and descending pain inhibitory system to analgesic effect of lemon odor in mice |
title_full | Contribution of anterior cingulate cortex and descending pain inhibitory system to analgesic effect of lemon odor in mice |
title_fullStr | Contribution of anterior cingulate cortex and descending pain inhibitory system to analgesic effect of lemon odor in mice |
title_full_unstemmed | Contribution of anterior cingulate cortex and descending pain inhibitory system to analgesic effect of lemon odor in mice |
title_short | Contribution of anterior cingulate cortex and descending pain inhibitory system to analgesic effect of lemon odor in mice |
title_sort | contribution of anterior cingulate cortex and descending pain inhibitory system to analgesic effect of lemon odor in mice |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936890/ https://www.ncbi.nlm.nih.gov/pubmed/24555533 http://dx.doi.org/10.1186/1744-8069-10-14 |
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