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WNK1-OSR1 kinase-mediated phospho-activation of Na(+)-K(+)-2Cl(-) cotransporter facilitates glioma migration

BACKGROUND: The bumetanide (BMT)-sensitive Na(+)-K(+)-2Cl(-) cotransporter isoform 1 (NKCC1) maintains cell volume homeostasis by increasing intracellular K(+) and Cl(-) content via regulatory volume increase (RVI). Expression levels of NKCC1 positively correlate with the histological grade and seve...

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Detalles Bibliográficos
Autores principales:	Zhu, Wen, Begum, Gulnaz, Pointer, Kelli, Clark, Paul A, Yang, Sung-Sen, Lin, Shih-Hua, Kahle, Kristopher T, Kuo, John S, Sun, Dandan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3936893/ https://www.ncbi.nlm.nih.gov/pubmed/24555568 http://dx.doi.org/10.1186/1476-4598-13-31

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