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Carotid surgery affects plasma kynurenic acid concentration: A pilot study
BACKGROUND: An increase in plasma kynurenic acid (KYNA) concentration has been observed following surgery, inflammation, and cerebral pathologies. The aim of the present study was to analyze the changes in plasma KYNA concentration in patients undergoing carotid surgery (CS). MATERIAL/METHODS: Adult...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scientific Literature, Inc.
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937007/ https://www.ncbi.nlm.nih.gov/pubmed/24561546 http://dx.doi.org/10.12659/MSM.890212 |
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author | Terlecki, Piotr Pawlik, Paulina Iwaniuk, Adam Kocki, Tomasz Przywara, Stanisław Ilzecki, Marek Zubilewicz, Tomasz Kowalczyk, Michał Parada-Turska, Jolanta Dąbrowski, Wojciech |
author_facet | Terlecki, Piotr Pawlik, Paulina Iwaniuk, Adam Kocki, Tomasz Przywara, Stanisław Ilzecki, Marek Zubilewicz, Tomasz Kowalczyk, Michał Parada-Turska, Jolanta Dąbrowski, Wojciech |
author_sort | Terlecki, Piotr |
collection | PubMed |
description | BACKGROUND: An increase in plasma kynurenic acid (KYNA) concentration has been observed following surgery, inflammation, and cerebral pathologies. The aim of the present study was to analyze the changes in plasma KYNA concentration in patients undergoing carotid surgery (CS). MATERIAL/METHODS: Adult patients undergoing elective carotid endarterectomy (CEA) or carotid angioplasty with stent placement (CAS) were studied. Plasma KYNA concentrations were analyzed before surgery and at 4 time points after CS. The amount of inflammation was measured as neutrophil-lymphocyte ratio (NLR). RESULTS: Forty patients (10 female and 30 male) aged 55–86 years of age were evaluated in this study. In patients with unstable carotid plaque, the plasma KYNA concentration was higher than in patients with stable carotid plaque. Moreover, the NLR was significantly higher in patients with unstable carotid plaque undergoing CEA than in patients undergoing CAS. Plasma KYNA concentration increased after surgery in patients undergoing CEA and CAS. There was a strong correlation between plasma KYNA concentration and NLR in patients with postoperative neurological disorders. CONCLUSIONS: CS increases plasma KYNA concentration, and changes in plasma KYNA concentration can indicate neurologic outcomes in patients undergoing CS. |
format | Online Article Text |
id | pubmed-3937007 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | International Scientific Literature, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-39370072014-02-28 Carotid surgery affects plasma kynurenic acid concentration: A pilot study Terlecki, Piotr Pawlik, Paulina Iwaniuk, Adam Kocki, Tomasz Przywara, Stanisław Ilzecki, Marek Zubilewicz, Tomasz Kowalczyk, Michał Parada-Turska, Jolanta Dąbrowski, Wojciech Med Sci Monit Clinical Research BACKGROUND: An increase in plasma kynurenic acid (KYNA) concentration has been observed following surgery, inflammation, and cerebral pathologies. The aim of the present study was to analyze the changes in plasma KYNA concentration in patients undergoing carotid surgery (CS). MATERIAL/METHODS: Adult patients undergoing elective carotid endarterectomy (CEA) or carotid angioplasty with stent placement (CAS) were studied. Plasma KYNA concentrations were analyzed before surgery and at 4 time points after CS. The amount of inflammation was measured as neutrophil-lymphocyte ratio (NLR). RESULTS: Forty patients (10 female and 30 male) aged 55–86 years of age were evaluated in this study. In patients with unstable carotid plaque, the plasma KYNA concentration was higher than in patients with stable carotid plaque. Moreover, the NLR was significantly higher in patients with unstable carotid plaque undergoing CEA than in patients undergoing CAS. Plasma KYNA concentration increased after surgery in patients undergoing CEA and CAS. There was a strong correlation between plasma KYNA concentration and NLR in patients with postoperative neurological disorders. CONCLUSIONS: CS increases plasma KYNA concentration, and changes in plasma KYNA concentration can indicate neurologic outcomes in patients undergoing CS. International Scientific Literature, Inc. 2014-02-24 /pmc/articles/PMC3937007/ /pubmed/24561546 http://dx.doi.org/10.12659/MSM.890212 Text en © Med Sci Monit, 2014 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License |
spellingShingle | Clinical Research Terlecki, Piotr Pawlik, Paulina Iwaniuk, Adam Kocki, Tomasz Przywara, Stanisław Ilzecki, Marek Zubilewicz, Tomasz Kowalczyk, Michał Parada-Turska, Jolanta Dąbrowski, Wojciech Carotid surgery affects plasma kynurenic acid concentration: A pilot study |
title | Carotid surgery affects plasma kynurenic acid concentration: A pilot study |
title_full | Carotid surgery affects plasma kynurenic acid concentration: A pilot study |
title_fullStr | Carotid surgery affects plasma kynurenic acid concentration: A pilot study |
title_full_unstemmed | Carotid surgery affects plasma kynurenic acid concentration: A pilot study |
title_short | Carotid surgery affects plasma kynurenic acid concentration: A pilot study |
title_sort | carotid surgery affects plasma kynurenic acid concentration: a pilot study |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937007/ https://www.ncbi.nlm.nih.gov/pubmed/24561546 http://dx.doi.org/10.12659/MSM.890212 |
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