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The relationship between mTOR signalling pathway and recombinant antibody productivity in CHO cell lines
BACKGROUND: High recombinant protein productivity in mammalian cell lines is often associated with phenotypic changes in protein content, energy metabolism, and cell growth, but the key determinants that regulate productivity are still not clearly understood. The mammalian target of rapamycin (mTOR)...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937030/ https://www.ncbi.nlm.nih.gov/pubmed/24533650 http://dx.doi.org/10.1186/1472-6750-14-15 |