D-2-Hydroxyglutarate producing neo-enzymatic activity inversely correlates with frequency of the type of isocitrate dehydrogenase 1 mutations found in glioma

BACKGROUND: IDH mutations frequently occur in diffuse gliomas and result in a neo-enzymatic activity that results in reduction of α-ketoglutarate to D-2-hydroxyglutarate. In gliomas, the frequency of IDH1 mutations in codon 132 increases in the order R132L-R132S-R132G-R132C-R132H with R132H constitu...

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Detalles Bibliográficos
Autores principales: Pusch, Stefan, Schweizer, Leonille, Beck, Ann-Christin, Lehmler, Johanna-Marie, Weissert, Susanne, Balss, Jörg, Miller, Aubry K, von Deimling, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937031/
https://www.ncbi.nlm.nih.gov/pubmed/24529257
http://dx.doi.org/10.1186/2051-5960-2-19

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