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Interaction of Nck1 and PERK phosphorylated at Y(561) negatively modulates PERK activity and PERK regulation of pancreatic β-cell proinsulin content
PERK, the PKR-like endoplasmic reticulum (ER) kinase, is an ER transmembrane serine/threonine protein kinase activated during ER stress. In this study, we provide evidence that the Src-homology domain–containing adaptor Nck1 negatively regulates PERK. We show that Nck directly binds to phosphorylate...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937095/ https://www.ncbi.nlm.nih.gov/pubmed/24371088 http://dx.doi.org/10.1091/mbc.E13-09-0511 |