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Bacterial microbiome of lungs in COPD
Chronic obstructive pulmonary disease (COPD) is currently the third leading cause of death in the world. Although smoking is the main risk factor for this disease, only a minority of smokers develop COPD. Why this happens is largely unknown. Recent discoveries by the human microbiome project have sh...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937108/ https://www.ncbi.nlm.nih.gov/pubmed/24591822 http://dx.doi.org/10.2147/COPD.S38932 |
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author | Sze, Marc A Hogg, James C Sin, Don D |
author_facet | Sze, Marc A Hogg, James C Sin, Don D |
author_sort | Sze, Marc A |
collection | PubMed |
description | Chronic obstructive pulmonary disease (COPD) is currently the third leading cause of death in the world. Although smoking is the main risk factor for this disease, only a minority of smokers develop COPD. Why this happens is largely unknown. Recent discoveries by the human microbiome project have shed new light on the importance and richness of the bacterial microbiota at different body sites in human beings. The microbiota plays a particularly important role in the development and functional integrity of the immune system. Shifts or perturbations in the microbiota can lead to disease. COPD is in part mediated by dysregulated immune responses to cigarette smoke and other environmental insults. Although traditionally the lung has been viewed as a sterile organ, by using highly sensitive genomic techniques, recent reports have identified diverse bacterial communities in the human lung that may change in COPD. This review summarizes the current knowledge concerning the lung microbiota in COPD and its potential implications for pathogenesis of the disease. |
format | Online Article Text |
id | pubmed-3937108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-39371082014-03-03 Bacterial microbiome of lungs in COPD Sze, Marc A Hogg, James C Sin, Don D Int J Chron Obstruct Pulmon Dis Review Chronic obstructive pulmonary disease (COPD) is currently the third leading cause of death in the world. Although smoking is the main risk factor for this disease, only a minority of smokers develop COPD. Why this happens is largely unknown. Recent discoveries by the human microbiome project have shed new light on the importance and richness of the bacterial microbiota at different body sites in human beings. The microbiota plays a particularly important role in the development and functional integrity of the immune system. Shifts or perturbations in the microbiota can lead to disease. COPD is in part mediated by dysregulated immune responses to cigarette smoke and other environmental insults. Although traditionally the lung has been viewed as a sterile organ, by using highly sensitive genomic techniques, recent reports have identified diverse bacterial communities in the human lung that may change in COPD. This review summarizes the current knowledge concerning the lung microbiota in COPD and its potential implications for pathogenesis of the disease. Dove Medical Press 2014-02-21 /pmc/articles/PMC3937108/ /pubmed/24591822 http://dx.doi.org/10.2147/COPD.S38932 Text en © 2014 Sze et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Sze, Marc A Hogg, James C Sin, Don D Bacterial microbiome of lungs in COPD |
title | Bacterial microbiome of lungs in COPD |
title_full | Bacterial microbiome of lungs in COPD |
title_fullStr | Bacterial microbiome of lungs in COPD |
title_full_unstemmed | Bacterial microbiome of lungs in COPD |
title_short | Bacterial microbiome of lungs in COPD |
title_sort | bacterial microbiome of lungs in copd |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937108/ https://www.ncbi.nlm.nih.gov/pubmed/24591822 http://dx.doi.org/10.2147/COPD.S38932 |
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