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Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation
Rapid and reversible methods for altering the level of endogenous proteins are critically important for studying biological systems and developing therapeutics. Here, we describe a membrane permeable targeting peptide-based method that rapidly and reversibly knocks down endogenous proteins through c...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937121/ https://www.ncbi.nlm.nih.gov/pubmed/24464042 http://dx.doi.org/10.1038/nn.3637 |