A Novel Bayesian Method for Detection of APOBEC3-Mediated Hypermutation and Its Application to Zoonotic Transmission of Simian Foamy Viruses

Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely u...

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Detalles Bibliográficos
Autores principales: Matsen, Frederick A., Small, Christopher T., Soliven, Khanh, Engel, Gregory A., Feeroz, Mostafa M., Wang, Xiaoxing, Craig, Karen L., Hasan, M. Kamrul, Emerman, Michael, Linial, Maxine L., Jones-Engel, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937129/
https://www.ncbi.nlm.nih.gov/pubmed/24586139
http://dx.doi.org/10.1371/journal.pcbi.1003493
Descripción
Sumario:Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely understood. In this paper we develop a new Bayesian approach to the detection of APOBEC3-mediated hypermutation, and use it to compare SFV sequences from human and NHP hosts living in close proximity in Bangladesh. We find that human APOBEC3G can induce genetic changes that may prevent SFV replication in infected humans in vivo.

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