A Novel Bayesian Method for Detection of APOBEC3-Mediated Hypermutation and Its Application to Zoonotic Transmission of Simian Foamy Viruses

Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely u...

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Autores principales: Matsen, Frederick A., Small, Christopher T., Soliven, Khanh, Engel, Gregory A., Feeroz, Mostafa M., Wang, Xiaoxing, Craig, Karen L., Hasan, M. Kamrul, Emerman, Michael, Linial, Maxine L., Jones-Engel, Lisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937129/
https://www.ncbi.nlm.nih.gov/pubmed/24586139
http://dx.doi.org/10.1371/journal.pcbi.1003493
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author Matsen, Frederick A.
Small, Christopher T.
Soliven, Khanh
Engel, Gregory A.
Feeroz, Mostafa M.
Wang, Xiaoxing
Craig, Karen L.
Hasan, M. Kamrul
Emerman, Michael
Linial, Maxine L.
Jones-Engel, Lisa
author_facet Matsen, Frederick A.
Small, Christopher T.
Soliven, Khanh
Engel, Gregory A.
Feeroz, Mostafa M.
Wang, Xiaoxing
Craig, Karen L.
Hasan, M. Kamrul
Emerman, Michael
Linial, Maxine L.
Jones-Engel, Lisa
author_sort Matsen, Frederick A.
collection PubMed
description Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely understood. In this paper we develop a new Bayesian approach to the detection of APOBEC3-mediated hypermutation, and use it to compare SFV sequences from human and NHP hosts living in close proximity in Bangladesh. We find that human APOBEC3G can induce genetic changes that may prevent SFV replication in infected humans in vivo.
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spelling pubmed-39371292014-03-04 A Novel Bayesian Method for Detection of APOBEC3-Mediated Hypermutation and Its Application to Zoonotic Transmission of Simian Foamy Viruses Matsen, Frederick A. Small, Christopher T. Soliven, Khanh Engel, Gregory A. Feeroz, Mostafa M. Wang, Xiaoxing Craig, Karen L. Hasan, M. Kamrul Emerman, Michael Linial, Maxine L. Jones-Engel, Lisa PLoS Comput Biol Research Article Simian Foamy Virus (SFV) can be transmitted from non-human primates (NHP) to humans. However, there are no documented cases of human to human transmission, and significant differences exist between infection in NHP and human hosts. The mechanism for these between-host differences is not completely understood. In this paper we develop a new Bayesian approach to the detection of APOBEC3-mediated hypermutation, and use it to compare SFV sequences from human and NHP hosts living in close proximity in Bangladesh. We find that human APOBEC3G can induce genetic changes that may prevent SFV replication in infected humans in vivo. Public Library of Science 2014-02-27 /pmc/articles/PMC3937129/ /pubmed/24586139 http://dx.doi.org/10.1371/journal.pcbi.1003493 Text en © 2014 Matsen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Matsen, Frederick A.
Small, Christopher T.
Soliven, Khanh
Engel, Gregory A.
Feeroz, Mostafa M.
Wang, Xiaoxing
Craig, Karen L.
Hasan, M. Kamrul
Emerman, Michael
Linial, Maxine L.
Jones-Engel, Lisa
A Novel Bayesian Method for Detection of APOBEC3-Mediated Hypermutation and Its Application to Zoonotic Transmission of Simian Foamy Viruses
title A Novel Bayesian Method for Detection of APOBEC3-Mediated Hypermutation and Its Application to Zoonotic Transmission of Simian Foamy Viruses
title_full A Novel Bayesian Method for Detection of APOBEC3-Mediated Hypermutation and Its Application to Zoonotic Transmission of Simian Foamy Viruses
title_fullStr A Novel Bayesian Method for Detection of APOBEC3-Mediated Hypermutation and Its Application to Zoonotic Transmission of Simian Foamy Viruses
title_full_unstemmed A Novel Bayesian Method for Detection of APOBEC3-Mediated Hypermutation and Its Application to Zoonotic Transmission of Simian Foamy Viruses
title_short A Novel Bayesian Method for Detection of APOBEC3-Mediated Hypermutation and Its Application to Zoonotic Transmission of Simian Foamy Viruses
title_sort novel bayesian method for detection of apobec3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937129/
https://www.ncbi.nlm.nih.gov/pubmed/24586139
http://dx.doi.org/10.1371/journal.pcbi.1003493
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