Effect of omega-3 supplementation versus placebo on acylation stimulating protein receptor gene expression in type 2 diabetics

BACKGROUND: This randomized controlled trial investigated the role of omega-3 supplementation on C5L2 gene expression in type 2 diabetics. METHODS: Subjects in the omega-3 group received 4 g omega-3 per day and subjects in the placebo group took four capsules of placebo per day for 10 weeks. Gene ex...

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Autores principales: Farahbakhsh-Farsi, Payam, Djalali, Mahmoud, Koohdani, Fariba, Saboor-Yaraghi, Ali Akbar, Eshraghian, Mohammad Reza, Javanbakht, Mohammad Hassan, Chamari, Maryam, Djazayery, Abolghassem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937173/
https://www.ncbi.nlm.nih.gov/pubmed/24393631
http://dx.doi.org/10.1186/2251-6581-13-1
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author Farahbakhsh-Farsi, Payam
Djalali, Mahmoud
Koohdani, Fariba
Saboor-Yaraghi, Ali Akbar
Eshraghian, Mohammad Reza
Javanbakht, Mohammad Hassan
Chamari, Maryam
Djazayery, Abolghassem
author_facet Farahbakhsh-Farsi, Payam
Djalali, Mahmoud
Koohdani, Fariba
Saboor-Yaraghi, Ali Akbar
Eshraghian, Mohammad Reza
Javanbakht, Mohammad Hassan
Chamari, Maryam
Djazayery, Abolghassem
author_sort Farahbakhsh-Farsi, Payam
collection PubMed
description BACKGROUND: This randomized controlled trial investigated the role of omega-3 supplementation on C5L2 gene expression in type 2 diabetics. METHODS: Subjects in the omega-3 group received 4 g omega-3 per day and subjects in the placebo group took four capsules of placebo per day for 10 weeks. Gene expression was measured by RT- PCR at the beginning and end of the study. RESULTS: The results of this study show depletion in the omega-3 group, but the mean difference between two groups was not significant. CONCLUSIONS: Understanding the effect of the omega-3 pathway could contribute to targeting treatment of diabetes and its comorbidities.
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spelling pubmed-39371732014-02-28 Effect of omega-3 supplementation versus placebo on acylation stimulating protein receptor gene expression in type 2 diabetics Farahbakhsh-Farsi, Payam Djalali, Mahmoud Koohdani, Fariba Saboor-Yaraghi, Ali Akbar Eshraghian, Mohammad Reza Javanbakht, Mohammad Hassan Chamari, Maryam Djazayery, Abolghassem J Diabetes Metab Disord Research Article BACKGROUND: This randomized controlled trial investigated the role of omega-3 supplementation on C5L2 gene expression in type 2 diabetics. METHODS: Subjects in the omega-3 group received 4 g omega-3 per day and subjects in the placebo group took four capsules of placebo per day for 10 weeks. Gene expression was measured by RT- PCR at the beginning and end of the study. RESULTS: The results of this study show depletion in the omega-3 group, but the mean difference between two groups was not significant. CONCLUSIONS: Understanding the effect of the omega-3 pathway could contribute to targeting treatment of diabetes and its comorbidities. BioMed Central 2014-01-06 /pmc/articles/PMC3937173/ /pubmed/24393631 http://dx.doi.org/10.1186/2251-6581-13-1 Text en Copyright © 2014 Farahbakhsh-Farsi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Farahbakhsh-Farsi, Payam
Djalali, Mahmoud
Koohdani, Fariba
Saboor-Yaraghi, Ali Akbar
Eshraghian, Mohammad Reza
Javanbakht, Mohammad Hassan
Chamari, Maryam
Djazayery, Abolghassem
Effect of omega-3 supplementation versus placebo on acylation stimulating protein receptor gene expression in type 2 diabetics
title Effect of omega-3 supplementation versus placebo on acylation stimulating protein receptor gene expression in type 2 diabetics
title_full Effect of omega-3 supplementation versus placebo on acylation stimulating protein receptor gene expression in type 2 diabetics
title_fullStr Effect of omega-3 supplementation versus placebo on acylation stimulating protein receptor gene expression in type 2 diabetics
title_full_unstemmed Effect of omega-3 supplementation versus placebo on acylation stimulating protein receptor gene expression in type 2 diabetics
title_short Effect of omega-3 supplementation versus placebo on acylation stimulating protein receptor gene expression in type 2 diabetics
title_sort effect of omega-3 supplementation versus placebo on acylation stimulating protein receptor gene expression in type 2 diabetics
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937173/
https://www.ncbi.nlm.nih.gov/pubmed/24393631
http://dx.doi.org/10.1186/2251-6581-13-1
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