Targeting human CD27 with an agonist antibody stimulates T-cell activation and antitumor immunity

CD27 is an important co-stimulatory receptor of T cells that can potentially be exploited for immunotherapy. We developed a human IgG1 antibody that targets human CD27, and demonstrated its immunostimulatory and antineoplastic activity in various preclinical models. Currently, the antibody (1F5, CDX...

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Detalles Bibliográficos
Autores principales: Thomas, Lawrence J, He, Li-Zhen, Marsh, Henry, Keler, Tibor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937191/
https://www.ncbi.nlm.nih.gov/pubmed/24605266
http://dx.doi.org/10.4161/onci.27255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937191/
https://www.ncbi.nlm.nih.gov/pubmed/24605266
http://dx.doi.org/10.4161/onci.27255

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