Insertional Mutagenesis and Deep Profiling Reveals Gene Hierarchies and a Myc/p53-Dependent Bottleneck in Lymphomagenesis

Retroviral insertional mutagenesis (RIM) is a powerful tool for cancer genomics that was combined in this study with deep sequencing (RIM/DS) to facilitate a comprehensive analysis of lymphoma progression. Transgenic mice expressing two potent collaborating oncogenes in the germ line (CD2-MYC, -Runx...

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Detalles Bibliográficos
Autores principales: Huser, Camille A., Gilroy, Kathryn L., de Ridder, Jeroen, Kilbey, Anna, Borland, Gillian, Mackay, Nancy, Jenkins, Alma, Bell, Margaret, Herzyk, Pawel, van der Weyden, Louise, Adams, David J., Rust, Alistair G., Cameron, Ewan, Neil, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937229/
https://www.ncbi.nlm.nih.gov/pubmed/24586197
http://dx.doi.org/10.1371/journal.pgen.1004167

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937229/
https://www.ncbi.nlm.nih.gov/pubmed/24586197
http://dx.doi.org/10.1371/journal.pgen.1004167

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