Mice Carrying a Hypomorphic Evi1 Allele Are Embryonic Viable but Exhibit Severe Congenital Heart Defects

The ecotropic viral integration site 1 (Evi1) oncogenic transcription factor is one of a number of alternative transcripts encoded by the Mds1 and Evi1 complex locus (Mecom). Overexpression of Evi1 has been observed in a number of myeloid disorders and is associated with poor patient survival. It is...

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Detalles Bibliográficos
Autores principales: Bard-Chapeau, Emilie A., Szumska, Dorota, Jacob, Bindya, Chua, Belinda Q. L., Chatterjee, Gouri C., Zhang, Yi, Ward, Jerrold M., Urun, Fatma, Kinameri, Emi, Vincent, Stéphane D., Ahmed, Sayadi, Bhattacharya, Shoumo, Osato, Motomi, Perkins, Archibald S., Moore, Adrian W., Jenkins, Nancy A., Copeland, Neal G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937339/
https://www.ncbi.nlm.nih.gov/pubmed/24586749
http://dx.doi.org/10.1371/journal.pone.0089397

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