Development of Pre-Clinical Models for Evaluating the Therapeutic Potential of Candidate siRNA Targeting STAT6

Developing siRNA therapeutics poses technical challenges including appropriate molecular design and testing in suitable pre-clinical models. We previously detailed sequence-selection and modification strategies for siRNA candidates targeting STAT6. Here, we describe methodology that evaluates the su...

Descripción completa

Detalles Bibliográficos
Autores principales: Healey, Gareth D., Lockridge, Jennifer A., Zinnen, Shawn, Hopkin, Julian M., Richards, Ivan, Walker, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937390/
https://www.ncbi.nlm.nih.gov/pubmed/24587331
http://dx.doi.org/10.1371/journal.pone.0090338

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937390/
https://www.ncbi.nlm.nih.gov/pubmed/24587331
http://dx.doi.org/10.1371/journal.pone.0090338

Ejemplares similares