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Murine Model for Fusarium oxysporum Invasive Fusariosis Reveals Organ-Specific Structures for Dissemination and Long-Term Persistence

The soil-borne plant pathogen Fusarium oxysporum causes life-threatening invasive fusariosis in immunocompromised individuals. The mechanism of infection in mammalian hosts is largely unknown. In the present study we show that the symptoms of disseminated fusariosis caused by F. oxysporum in immunos...

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Autores principales: Schäfer, Katja, Di Pietro, Antonio, Gow, Neil A. R., MacCallum, Donna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937399/
https://www.ncbi.nlm.nih.gov/pubmed/24587124
http://dx.doi.org/10.1371/journal.pone.0089920
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author Schäfer, Katja
Di Pietro, Antonio
Gow, Neil A. R.
MacCallum, Donna
author_facet Schäfer, Katja
Di Pietro, Antonio
Gow, Neil A. R.
MacCallum, Donna
author_sort Schäfer, Katja
collection PubMed
description The soil-borne plant pathogen Fusarium oxysporum causes life-threatening invasive fusariosis in immunocompromised individuals. The mechanism of infection in mammalian hosts is largely unknown. In the present study we show that the symptoms of disseminated fusariosis caused by F. oxysporum in immunosuppressed mice are remarkably similar to those reported in humans. Distinct fungal structures were observed inside the host, depending on the infected organ. Invasive hyphae developed in the heart and kidney, causing massive colonization of the organs. By contrast, chlamydospore-like survival structures were found in lung, spleen and liver. Systemically infected mice also developed skin and eye infections, as well as thrombosis and necrosis in the tail. We further show that F. oxysporum can disseminate and persist in the organs of immunocompetent animals, and that these latent infections can lead to lethal systemic fusariosis if the host is later subjected to immunosuppressive treatment.
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spelling pubmed-39373992014-03-04 Murine Model for Fusarium oxysporum Invasive Fusariosis Reveals Organ-Specific Structures for Dissemination and Long-Term Persistence Schäfer, Katja Di Pietro, Antonio Gow, Neil A. R. MacCallum, Donna PLoS One Research Article The soil-borne plant pathogen Fusarium oxysporum causes life-threatening invasive fusariosis in immunocompromised individuals. The mechanism of infection in mammalian hosts is largely unknown. In the present study we show that the symptoms of disseminated fusariosis caused by F. oxysporum in immunosuppressed mice are remarkably similar to those reported in humans. Distinct fungal structures were observed inside the host, depending on the infected organ. Invasive hyphae developed in the heart and kidney, causing massive colonization of the organs. By contrast, chlamydospore-like survival structures were found in lung, spleen and liver. Systemically infected mice also developed skin and eye infections, as well as thrombosis and necrosis in the tail. We further show that F. oxysporum can disseminate and persist in the organs of immunocompetent animals, and that these latent infections can lead to lethal systemic fusariosis if the host is later subjected to immunosuppressive treatment. Public Library of Science 2014-02-27 /pmc/articles/PMC3937399/ /pubmed/24587124 http://dx.doi.org/10.1371/journal.pone.0089920 Text en © 2014 Schäfer et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Schäfer, Katja
Di Pietro, Antonio
Gow, Neil A. R.
MacCallum, Donna
Murine Model for Fusarium oxysporum Invasive Fusariosis Reveals Organ-Specific Structures for Dissemination and Long-Term Persistence
title Murine Model for Fusarium oxysporum Invasive Fusariosis Reveals Organ-Specific Structures for Dissemination and Long-Term Persistence
title_full Murine Model for Fusarium oxysporum Invasive Fusariosis Reveals Organ-Specific Structures for Dissemination and Long-Term Persistence
title_fullStr Murine Model for Fusarium oxysporum Invasive Fusariosis Reveals Organ-Specific Structures for Dissemination and Long-Term Persistence
title_full_unstemmed Murine Model for Fusarium oxysporum Invasive Fusariosis Reveals Organ-Specific Structures for Dissemination and Long-Term Persistence
title_short Murine Model for Fusarium oxysporum Invasive Fusariosis Reveals Organ-Specific Structures for Dissemination and Long-Term Persistence
title_sort murine model for fusarium oxysporum invasive fusariosis reveals organ-specific structures for dissemination and long-term persistence
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937399/
https://www.ncbi.nlm.nih.gov/pubmed/24587124
http://dx.doi.org/10.1371/journal.pone.0089920
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