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Mebendazole Reduces Vascular Smooth Muscle Cell Proliferation and Neointimal Formation Following Vascular Injury in Mice

Mebendazole is an antihelminthic drug that exerts its effects via interference with microtubule function in parasites. To determine the utility of mebendazole as a potential treatment for vascular diseases involving proliferation of vascular smooth muscle cells, the effects of mebendazole on vascula...

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Autores principales: Wang, Jintao, Wang, Hui, Guo, Chiao, Luo, Wei, Lawler, Alyssa, Reddy, Aswin, Wang, Julia, Sun, Eddy B., Eitzman, Daniel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937425/
https://www.ncbi.nlm.nih.gov/pubmed/24587248
http://dx.doi.org/10.1371/journal.pone.0090146
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author Wang, Jintao
Wang, Hui
Guo, Chiao
Luo, Wei
Lawler, Alyssa
Reddy, Aswin
Wang, Julia
Sun, Eddy B.
Eitzman, Daniel T.
author_facet Wang, Jintao
Wang, Hui
Guo, Chiao
Luo, Wei
Lawler, Alyssa
Reddy, Aswin
Wang, Julia
Sun, Eddy B.
Eitzman, Daniel T.
author_sort Wang, Jintao
collection PubMed
description Mebendazole is an antihelminthic drug that exerts its effects via interference with microtubule function in parasites. To determine the utility of mebendazole as a potential treatment for vascular diseases involving proliferation of vascular smooth muscle cells, the effects of mebendazole on vascular smooth muscle cell proliferation were tested in vitro and in a mouse model of arterial injury. In vitro, mebendazole inhibited proliferation and migration of murine vascular smooth muscle cells and this was associated with altered intracellular microtubule organization. To determine in vivo effects of mebendazole following vascular injury, femoral arterial wire injury was induced in wild-type mice treated with either mebendazole or placebo control. Compared with placebo-treated mice, mebendazole-treated mice formed less neointima at the site of injury. Mebendazole is effective at inhibiting vascular smooth muscle cell proliferation and migration, and neointimal formation following arterial injury in mice.
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spelling pubmed-39374252014-03-04 Mebendazole Reduces Vascular Smooth Muscle Cell Proliferation and Neointimal Formation Following Vascular Injury in Mice Wang, Jintao Wang, Hui Guo, Chiao Luo, Wei Lawler, Alyssa Reddy, Aswin Wang, Julia Sun, Eddy B. Eitzman, Daniel T. PLoS One Research Article Mebendazole is an antihelminthic drug that exerts its effects via interference with microtubule function in parasites. To determine the utility of mebendazole as a potential treatment for vascular diseases involving proliferation of vascular smooth muscle cells, the effects of mebendazole on vascular smooth muscle cell proliferation were tested in vitro and in a mouse model of arterial injury. In vitro, mebendazole inhibited proliferation and migration of murine vascular smooth muscle cells and this was associated with altered intracellular microtubule organization. To determine in vivo effects of mebendazole following vascular injury, femoral arterial wire injury was induced in wild-type mice treated with either mebendazole or placebo control. Compared with placebo-treated mice, mebendazole-treated mice formed less neointima at the site of injury. Mebendazole is effective at inhibiting vascular smooth muscle cell proliferation and migration, and neointimal formation following arterial injury in mice. Public Library of Science 2014-02-27 /pmc/articles/PMC3937425/ /pubmed/24587248 http://dx.doi.org/10.1371/journal.pone.0090146 Text en © 2014 Wang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wang, Jintao
Wang, Hui
Guo, Chiao
Luo, Wei
Lawler, Alyssa
Reddy, Aswin
Wang, Julia
Sun, Eddy B.
Eitzman, Daniel T.
Mebendazole Reduces Vascular Smooth Muscle Cell Proliferation and Neointimal Formation Following Vascular Injury in Mice
title Mebendazole Reduces Vascular Smooth Muscle Cell Proliferation and Neointimal Formation Following Vascular Injury in Mice
title_full Mebendazole Reduces Vascular Smooth Muscle Cell Proliferation and Neointimal Formation Following Vascular Injury in Mice
title_fullStr Mebendazole Reduces Vascular Smooth Muscle Cell Proliferation and Neointimal Formation Following Vascular Injury in Mice
title_full_unstemmed Mebendazole Reduces Vascular Smooth Muscle Cell Proliferation and Neointimal Formation Following Vascular Injury in Mice
title_short Mebendazole Reduces Vascular Smooth Muscle Cell Proliferation and Neointimal Formation Following Vascular Injury in Mice
title_sort mebendazole reduces vascular smooth muscle cell proliferation and neointimal formation following vascular injury in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937425/
https://www.ncbi.nlm.nih.gov/pubmed/24587248
http://dx.doi.org/10.1371/journal.pone.0090146
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