Functional Analysis Using Whole-Genome Sequencing of a Drug-Sensitive Mycobacterium tuberculosis Strain from Peru

We report the whole-genome sequence of a Latin American-Mediterranean (LAM) lineage drug-sensitive Mycobacterium tuberculosis strain from Peru, INS-SEN. The functional analysis revealed more mutations in secondary metabolite biosynthesis, transport, and catabolism (clusters of orthologous groups [CO...

Descripción completa

Detalles Bibliográficos
Autores principales: Tarazona, D., Borda, V., Galarza, M., Agapito, J. C., Guio, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Prokaryotes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937605/
https://www.ncbi.nlm.nih.gov/pubmed/24578269
http://dx.doi.org/10.1128/genomeA.00087-14
_version_ 1782305523881738240
author Tarazona, D.
Borda, V.
Galarza, M.
Agapito, J. C.
Guio, H.
author_facet Tarazona, D.
Borda, V.
Galarza, M.
Agapito, J. C.
Guio, H.
author_sort Tarazona, D.
collection PubMed
description We report the whole-genome sequence of a Latin American-Mediterranean (LAM) lineage drug-sensitive Mycobacterium tuberculosis strain from Peru, INS-SEN. The functional analysis revealed more mutations in secondary metabolite biosynthesis, transport, and catabolism (clusters of orthologous groups [COG] category Q) than for other LAM-sensitive strains. This study contributes to the understanding of the genomic diversity of drug-sensitive M. tuberculosis.
format Online
Article
Text
id pubmed-3937605
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-39376052014-03-04 Functional Analysis Using Whole-Genome Sequencing of a Drug-Sensitive Mycobacterium tuberculosis Strain from Peru Tarazona, D. Borda, V. Galarza, M. Agapito, J. C. Guio, H. Genome Announc Prokaryotes We report the whole-genome sequence of a Latin American-Mediterranean (LAM) lineage drug-sensitive Mycobacterium tuberculosis strain from Peru, INS-SEN. The functional analysis revealed more mutations in secondary metabolite biosynthesis, transport, and catabolism (clusters of orthologous groups [COG] category Q) than for other LAM-sensitive strains. This study contributes to the understanding of the genomic diversity of drug-sensitive M. tuberculosis. American Society for Microbiology 2014-02-27 /pmc/articles/PMC3937605/ /pubmed/24578269 http://dx.doi.org/10.1128/genomeA.00087-14 Text en Copyright © 2014 Tarazona et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Prokaryotes
Tarazona, D.
Borda, V.
Galarza, M.
Agapito, J. C.
Guio, H.
Functional Analysis Using Whole-Genome Sequencing of a Drug-Sensitive Mycobacterium tuberculosis Strain from Peru
title Functional Analysis Using Whole-Genome Sequencing of a Drug-Sensitive Mycobacterium tuberculosis Strain from Peru
title_full Functional Analysis Using Whole-Genome Sequencing of a Drug-Sensitive Mycobacterium tuberculosis Strain from Peru
title_fullStr Functional Analysis Using Whole-Genome Sequencing of a Drug-Sensitive Mycobacterium tuberculosis Strain from Peru
title_full_unstemmed Functional Analysis Using Whole-Genome Sequencing of a Drug-Sensitive Mycobacterium tuberculosis Strain from Peru
title_short Functional Analysis Using Whole-Genome Sequencing of a Drug-Sensitive Mycobacterium tuberculosis Strain from Peru
title_sort functional analysis using whole-genome sequencing of a drug-sensitive mycobacterium tuberculosis strain from peru
topic Prokaryotes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937605/
https://www.ncbi.nlm.nih.gov/pubmed/24578269
http://dx.doi.org/10.1128/genomeA.00087-14
work_keys_str_mv AT tarazonad functionalanalysisusingwholegenomesequencingofadrugsensitivemycobacteriumtuberculosisstrainfromperu
AT bordav functionalanalysisusingwholegenomesequencingofadrugsensitivemycobacteriumtuberculosisstrainfromperu
AT galarzam functionalanalysisusingwholegenomesequencingofadrugsensitivemycobacteriumtuberculosisstrainfromperu
AT agapitojc functionalanalysisusingwholegenomesequencingofadrugsensitivemycobacteriumtuberculosisstrainfromperu
AT guioh functionalanalysisusingwholegenomesequencingofadrugsensitivemycobacteriumtuberculosisstrainfromperu

Ejemplares similares