Evidence of Clonal Expansion in the Genome of a Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolate from Peru

We report the genome sequence of Mycobacterium tuberculosis INS-MDR from Peru, a multidrug-resistant tuberculosis (MDR-TB) and Latin American-Mediterranean (LAM) lineage strain. Our analysis showed mutations related to drug resistance in the rpoB (D516V), katG (S315T), kasA (G269S), and pncA (Q10R)...

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Detalles Bibliográficos
Autores principales: Galarza, M., Tarazona, D., Borda, V., Agapito, J. C., Guio, H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2014
Materias:
Prokaryotes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937606/
https://www.ncbi.nlm.nih.gov/pubmed/24578270
http://dx.doi.org/10.1128/genomeA.00089-14
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author Galarza, M.
Tarazona, D.
Borda, V.
Agapito, J. C.
Guio, H.
author_facet Galarza, M.
Tarazona, D.
Borda, V.
Agapito, J. C.
Guio, H.
author_sort Galarza, M.
collection PubMed
description We report the genome sequence of Mycobacterium tuberculosis INS-MDR from Peru, a multidrug-resistant tuberculosis (MDR-TB) and Latin American-Mediterranean (LAM) lineage strain. Our analysis showed mutations related to drug resistance in the rpoB (D516V), katG (S315T), kasA (G269S), and pncA (Q10R) genes. Our evidence suggests that INS-MDR may be a clonal expansion related to the African strain KZN 1435.
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spelling pubmed-39376062014-03-04 Evidence of Clonal Expansion in the Genome of a Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolate from Peru Galarza, M. Tarazona, D. Borda, V. Agapito, J. C. Guio, H. Genome Announc Prokaryotes We report the genome sequence of Mycobacterium tuberculosis INS-MDR from Peru, a multidrug-resistant tuberculosis (MDR-TB) and Latin American-Mediterranean (LAM) lineage strain. Our analysis showed mutations related to drug resistance in the rpoB (D516V), katG (S315T), kasA (G269S), and pncA (Q10R) genes. Our evidence suggests that INS-MDR may be a clonal expansion related to the African strain KZN 1435. American Society for Microbiology 2014-02-27 /pmc/articles/PMC3937606/ /pubmed/24578270 http://dx.doi.org/10.1128/genomeA.00089-14 Text en Copyright © 2014 Galarza et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Prokaryotes
Galarza, M.
Tarazona, D.
Borda, V.
Agapito, J. C.
Guio, H.
Evidence of Clonal Expansion in the Genome of a Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolate from Peru
title Evidence of Clonal Expansion in the Genome of a Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolate from Peru
title_full Evidence of Clonal Expansion in the Genome of a Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolate from Peru
title_fullStr Evidence of Clonal Expansion in the Genome of a Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolate from Peru
title_full_unstemmed Evidence of Clonal Expansion in the Genome of a Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolate from Peru
title_short Evidence of Clonal Expansion in the Genome of a Multidrug-Resistant Mycobacterium tuberculosis Clinical Isolate from Peru
title_sort evidence of clonal expansion in the genome of a multidrug-resistant mycobacterium tuberculosis clinical isolate from peru
topic Prokaryotes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937606/
https://www.ncbi.nlm.nih.gov/pubmed/24578270
http://dx.doi.org/10.1128/genomeA.00089-14
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