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Benzothiazinones Mediate Killing of Corynebacterineae by Blocking Decaprenyl Phosphate Recycling Involved in Cell Wall Biosynthesis

Benzothiazinones (BTZs) are a new class of sulfur containing heterocyclic compounds that target DprE1, an oxidoreductase involved in the epimerization of decaprenyl-phosphoribose (DPR) to decaprenyl-phosphoarabinose (DPA) in the Corynebacterineae, such as Corynebacterium glutamicum and Mycobacterium...

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Detalles Bibliográficos
Autores principales:	Grover, Shipra, Alderwick, Luke J., Mishra, Arun K., Krumbach, Karin, Marienhagen, Jan, Eggeling, Lothar, Bhatt, Apoorva, Besra, Gurdyal S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2014
Materias:	Glycobiology and Extracellular Matrices
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937683/ https://www.ncbi.nlm.nih.gov/pubmed/24446451 http://dx.doi.org/10.1074/jbc.M113.522623

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